Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 20/20 | 0.59 |
| ▸ | ICAM1 | P05362 | 20/20 | 0.59 |
| ▸ | ITGAL | P20701 | 20/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL879313 | 0.93 | ITGB2 (0.66) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL20903203 | 0.93 | ITGB2 (0.66) | ITGB2ICAM1ITGALCYP2C9 | |
| Hydrochloric Acid SCHEMBL20680588 | 0.92 | ITGB2 (0.65) | ITGB2ICAM1ITGALCYP2C9 | |
| Hydrochloric Acid SCHEMBL20680587 | 0.92 | ITGB2 (0.65) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL19134129 | 0.92 | ITGB2 (0.57) | ITGB2ICAM1ITGALCYP2C9 | |
| Hydrochloric Acid SCHEMBL29547703 | 0.91 | ITGB2 (0.55) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL24360217 | 0.89 | ITGB2 (0.54) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL20833731 | 0.89 | ITGB2 (0.55) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL13588337 | 0.89 | ITGB2 (0.55) | ITGB2ICAM1ITGALCYP2C9 | |
| Hydrochloric Acid SCHEMBL31021044 | 0.88 | ITGB2 (0.55) | ITGB2ICAM1ITGALCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118726-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | SARCODE BIOSCIENCE INC. (US) | 2018-05-03 | — | — | US | disclosed |
| US-9708303-B2 | LFA-1 inhibitor and methods of preparation and polymorph thereof | SARCODE BIOSCIENCE INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20150336939-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | SARCODE BIOSCIENCE INC. (US) | 2015-11-26 | — | — | US | disclosed |
| US-9085553-B2 | LFA-1 inhibitor and methods of preparation and polymorph thereof | SARcode Bioscience, Inc. (US) | 2015-07-21 | — | — | US | disclosed |
| US-20140031387-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | SARCODE BIOSCIENCE INC. (US) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031387-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | ITGB1, ITGA1, VCAM1 | ITGB2 10/4885ICAM1 7/4885ITGAL 4/4885 |
| US-20150336939-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | ITGB1, ITGA1, VCAM1 | ITGB2 10/4885ICAM1 7/4885ITGAL 4/4885 |
| US-20180118726-A1 | LFA-1 INHIBITOR AND METHODS OF PREPARATION AND POLYMORPH THEREOF | ITGB1, ITGA1, VCAM1 | ITGB2 10/4885ICAM1 7/4885ITGAL 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.