Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 7/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15442512 | 0.92 | FGFR1 (0.57) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL20144354 | 0.90 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL21017831 | 0.82 | HDAC6 (0.62) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL15442516 | 0.80 | HDAC6 (0.58) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL8262968 | 0.78 | FGFR1 (0.49) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL2934367 | 0.77 | LMNA (0.53) | HDAC6KITPARP1TNKS | |
| SCHEMBL21087550 | 0.76 | HDAC6 (0.58) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL15451449 | 0.75 | FGFR1 (0.60) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL28498762 | 0.72 | FGFR1 (0.54) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL30060858 | 0.72 | FGFR1 (0.54) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186247-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-2880038-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2018-05-16 | — | — | EP | disclosed |
| WO-2016029776-A1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2016-03-03 | — | — | WO | disclosed |
| US-9174996-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174996-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140364436-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364436-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-12-11 | — | — | US | disclosed |
| US-8859553-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859553-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2014-10-14 | — | — | US | disclosed |
| WO-2014019338-A1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2014-02-06 | — | — | WO | disclosed |
| US-20140031354-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-01-30 | — | — | US | disclosed |
| US-20140031354-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364436-A1 | Protein Kinase Inhibitors | MAP3K9, MAP3K6, MAP3K8 | HDAC3 1009/4885HDAC1 988/4885HDAC2 1044/4885 |
| US-20140031354-A1 | Protein Kinase Inhibitors | MAP3K1, MAP3K5, MAP3K7 | HDAC3 725/4885HDAC1 605/4885HDAC2 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.