Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.51 |
| ▸ | CHKA | P35790 | 6/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TNKS | O95271 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927003 | 0.87 | LMNA (0.53) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL21400973 | 0.86 | HRH3 (0.53) | NCF1PRMT6ALDH1A1KDM4E | |
| SCHEMBL14609609 | 0.84 | LMNA (0.58) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL26952893 | 0.81 | LMNA (0.59) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL18054024 | 0.80 | CHKA (0.59) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL22169184 | 0.80 | LMNA (0.62) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL2933199 | 0.80 | CRHBP (0.50) | LMNAMC4RCHKAALDH1A1KDM4E | |
| SCHEMBL2928518 | 0.79 | LMNA (0.51) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL1911878 | 0.78 | CRHBP (0.55) | LMNAMC4RCHKAALDH1A1KDM4E | |
| SCHEMBL22529530 | 0.77 | KIT (0.68) | ALDH1A1HDAC6KITNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |