Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL128635 | 0.88 | FBP1 (0.61) | FBP1NPC1LMNAMAPTKDM4E | |
| SCHEMBL27827007 | 0.81 | FBP1 (0.61) | FBP1LMNAMAPTALDH1A1HPGD | |
| SCHEMBL12829824 | 0.81 | FBP1 (0.52) | FBP1MAPTMEN1KMT2ATP53 | |
| SCHEMBL2134640 | 0.77 | MAPT (0.54) | FBP1NPC1LMNAMAPTKDM4E | |
| SCHEMBL1748081 | 0.76 | KDM4E (0.53) | FBP1NPC1LMNAMAPTKDM4E | |
| SCHEMBL15450923 | 0.75 | PIK3CA (0.51) | FBP1NPC1LMNAMAPTKDM4E | |
| SCHEMBL8034874 | 0.74 | MAPT (0.56) | FBP1NPC1LMNAMAPTKDM4E | |
| SCHEMBL11261015 | 0.73 | MAPT (0.50) | FBP1NPC1LMNAMAPTKDM4E | |
| SCHEMBL11258897 | 0.73 | AGPAT2 (0.58) | FBP1NPC1LMNAMAPTKDM4E | |
| SCHEMBL8370275 | 0.72 | NPC1 (0.66) | NPC1MAPTKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637542-B2 | Kinase inhibitors and methods of use | INTELLIKINE, INC. (US) | 2014-01-28 | — | — | US | disclosed |