Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 11/20 | 0.46 |
| ▸ | RAB9A | P51151 | 11/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3822363 | 0.87 | RAB9A (0.59) | MAPTKDM4EHSD17B10FBP1ALDH1A1 | |
| SCHEMBL12755430 | 0.80 | CSNK1D (0.49) | MAPTFBP1ELANEMEN1KMT2A | |
| SCHEMBL2134640 | 0.79 | MAPT (0.54) | MAPTKDM4EHSD17B10FBP1ALDH1A1 | |
| SCHEMBL2544239 | 0.79 | KDM4E (0.48) | MAPTKDM4EHSD17B10FBP1ALDH1A1 | |
| SCHEMBL29045541 | 0.78 | ELANE (0.44) | MAPTKDM4EFBP1ALDH1A1NPC1 | |
| SCHEMBL11451768 | 0.77 | ELANE (0.61) | MAPTALDH1A1LMNANPC1RAB9A | |
| SCHEMBL2841557 | 0.77 | TTR (0.49) | MAPTKDM4EALDH1A1TDP1LMNA | |
| SCHEMBL11261015 | 0.75 | MAPT (0.50) | MAPTKDM4EHSD17B10FBP1ALDH1A1 | |
| SCHEMBL5535594 | 0.75 | MAPT (0.83) | MAPTKDM4EHSD17B10ALDH1A1TDP1 | |
| SCHEMBL8370275 | 0.74 | NPC1 (0.66) | MAPTKDM4EHSD17B10ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637542-B2 | Kinase inhibitors and methods of use | INTELLIKINE, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| WO-2009114870-A2 | KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE, INC. (US) | 2009-09-17 | — | — | WO | disclosed |