⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789665 | 0.83 | — | — | |
| SCHEMBL2547540 | 0.81 | LMNA (0.57) | — | |
| SCHEMBL30525718 | 0.78 | LMNA (0.62) | — | |
| SCHEMBL27862143 | 0.75 | — | — | |
| Ethylene SCHEMBL21679941 | 0.75 | TSHR (0.52) | — | |
| SCHEMBL2745809 | 0.75 | LMNA (0.52) | — | |
| Formaldehyde SCHEMBL4454552 | 0.75 | TSHR (0.52) | — | |
| SCHEMBL2746597 | 0.75 | TSHR (0.52) | — | |
| SCHEMBL24835739 | 0.73 | TSHR (0.50) | — | |
| SCHEMBL5721317 | 0.73 | TSHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034810-B2 | Matrix metalloproteinase inhibitors; antiinflammatory agengs; rheumatoid arthritis, osteoarthritis; antitumor, anticarcinogenic, and antimetastasis agents; respiratory system disorders, chronic obstructive pulmonary disease, deblocking, deprotecting | NOVARTIS AG (CH) | 2011-10-11 | — | — | US | disclosed |
| EP-1202961-B1 | ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES | NOVARTIS AG (CH) | 2010-01-20 | — | — | EP | disclosed |
| EP-2085379-A1 | Arylsulfonamido-substituted hydroxamic acid derivatives | Novartis AG (CH) | 2009-08-05 | — | — | EP | disclosed |
| US-20080275127-A1 | Arylsulfonamido-substituted hydroxamic acid derivatives | BREITENSTEIN WERNER | 2008-11-06 | — | — | US | disclosed |
| EP-0938486-B1 | SUBSTITUTED PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2008-01-16 | — | — | EP | disclosed |
| US-7138432-B1 | Arylsulfonamido-substituted hydroxamic acid derivatives | NOVARTIS AG (CH) | 2006-11-21 | — | — | US | disclosed |
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |
| EP-0672042-B1 | PHARMACOLOGICALLY ACTIVE PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2006-05-03 | — | — | EP | disclosed |
| US-6767906-B2 | INHIBIT P34CDC2/CYCLIN BCDC13 KINASE AND PROTEIN TYROSINE KINASE PP60C-SRC AND CAN BE USED FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES, FOR EXAMPLE CHEMOTHERAPY OF TUMOURS OR OSTEOPOROSIS. | NOVARTIS AG (CH) | 2004-07-27 | — | — | US | disclosed |
| EP-1153024-B1 | 2-AMINO-6-ANILINO-PURINES AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2004-04-28 | — | — | EP | disclosed |
| EP-0239543-A2 | Glucose derivatives and methods for their preparation | CIBA-GEIGY AG (CH) | 1987-09-30 | — | — | EP | disclosed |
| US-4640911-A | IMMUNOSTIMULANTS, VIRICIDES SUCH AS HERPES SIMPLEX | CIBA-GEIGY CORPORATION (US) | 1987-02-03 | — | — | US | disclosed |
| EP-0192611-A2 | Acylated hexose derivatives and method for their preparation | CIBA-GEIGY AG (CH) | 1986-08-27 | — | — | EP | disclosed |
| EP-0188400-A2 | Oligopeptides, intermediates and process for their preparation | CIBA-GEIGY AG (CH) | 1986-07-23 | — | — | EP | disclosed |
| US-4595677-A | Substituted tetrapeptides | CIBA-GEIGY CORPORATION (US) | 1986-06-17 | — | — | US | disclosed |
| EP-0174912-A2 | Phosphorus compounds, process for their preparations and their use | CIBA-GEIGY AG (CH) | 1986-03-19 | — | — | EP | disclosed |
| EP-0169812-A1 | Phosphatidyl compounds, process for their preparation and their use | CIBA-GEIGY AG (CH) | 1986-01-29 | — | — | EP | disclosed |
| EP-0163286-A2 | Acylated sugars, method for their preparation and their use | CIBA-GEIGY AG (CH) | 1985-12-04 | — | — | EP | disclosed |
| US-4464366-A | Cephem compounds having a terminal aminocarboxylic acid grouping and containing an azacyclyl(thio)ureido group | CIBA GEIGY CORPORATION (US) | 1984-08-07 | — | — | US | disclosed |
| US-4423038-A | Phosphoryl compounds, pharmaceutical preparations containing such compounds, and their use | CIBA-GEIGY CORPORATION (US) | 1983-12-27 | — | — | US | disclosed |