SCHEMBL15460258

SCHEMBL15460258

c1cncc(-c2cc3c4cc(-c5cccnc5)c5ccccc5c4sc3c3ccccc23)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 5/20 0.60
CYP2A6 P11509 7/20 0.50
CYP3A4 P08684 3/20 0.47
ALDH1A1 P00352 1/20 0.47
CYP1A2 P05177 1/20 0.47
TDO2 P48775 1/20 0.44
CYP2E1 P05181 2/20 0.44
CYP2D6 P10635 2/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2B6 P20813 2/20 0.44
CYP2C19 P33261 2/20 0.44
CYP11B2 P19099 4/20 0.43
ALOX5 P09917 1/20 0.43
GPR84 Q9NQS5 1/20 0.43
IDO1 P14902 1/20 0.42
LRRK2 Q5S007 1/20 0.42
CYP19A1 P11511 2/20 0.42
DYRK1A Q13627 1/20 0.42
DYRK1B Q9Y463 1/20 0.42
CYP17A1 P05093 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15460263 0.90 CYP11B1 (0.49) CYP11B1CYP2A6CYP3A4ALDH1A1CYP1A2
SCHEMBL29293136 0.81 CYP11B1 (0.50) CYP11B1CYP2A6CYP3A4ALDH1A1CYP1A2
SCHEMBL29293019 0.81 CYP11B1 (0.50) CYP11B1CYP2A6CYP3A4ALDH1A1CYP1A2
SCHEMBL15460272 0.81 CYP2A6 (0.50) CYP11B1CYP2A6CYP3A4ALDH1A1CYP1A2
SCHEMBL29293180 0.80 CYP11B1 (0.49) CYP11B1CYP2A6ALDH1A1CYP1A2CYP11B2
SCHEMBL15460285 0.79 CYP11B1 (0.43) CYP11B1CYP2A6ALDH1A1CYP1A2TDO2
SCHEMBL29293249 0.79 CYP11B1 (0.47) CYP11B1CYP2A6CYP3A4ALDH1A1CYP1A2
SCHEMBL15460291 0.78 CYP11B1 (0.42) CYP11B1CYP2A6CYP3A4ALDH1A1CYP1A2
SCHEMBL15460275 0.78 PDK2 (0.42) CYP11B1CYP2A6CYP3A4ALDH1A1CYP1A2
SCHEMBL15460305 0.78 CYP11B1 (0.58) CYP11B1CYP2A6CYP3A4ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9385327-B2 Heterocyclic compound and organic light-emitting device including the same SAMSUNG DISPLAY CO., LTD. (KR) 2016-07-05 US disclosed
US-9385327-B2 Heterocyclic compound and organic light-emitting device including the same SAMSUNG DISPLAY CO., LTD. (KR) 2016-07-05 US disclosed
US-9349966-B2 2016-05-24 US disclosed
US-9349966-B2 2016-05-24 US disclosed
US-20140034915-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG DISPLAY CO. LTD. (KR) 2014-02-06 US disclosed
US-20140034915-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG DISPLAY CO. LTD. (KR) 2014-02-06 US disclosed