SCHEMBL15460375

SCHEMBL15460375

Cc1cc2ccc3cc(C)c(C)nc3c2nc1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 4/20 0.43
CCR5 P51681 3/20 0.43
RAB9A P51151 1/20 0.43
CCR8 P51685 3/20 0.42
NOS3 P29474 1/20 0.39
NOS1 P29475 1/20 0.39
NOS2 P35228 1/20 0.39
MAPT P10636 1/20 0.37
CYP1A2 P05177 3/20 0.35
CYP2A6 P11509 2/20 0.35
KMT2A Q03164 4/20 0.34
MEN1 O00255 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
GAA P10253 1/20 0.34
HTT P42858 1/20 0.34
TSHR P16473 1/20 0.34
NQO2 P16083 2/20 0.33
KDM4E B2RXH2 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL862358 0.89 CCR1 (0.65) CCR1CCR5RAB9ACCR8MAPT
SCHEMBL15624663 0.85 MEN1 (0.49) CCR1CCR5RAB9ACCR8NOS3
SCHEMBL15593262 0.85 CCR1 (0.38) CCR1CCR5RAB9ACCR8NOS3
SCHEMBL20412811 0.84 CCR1 (0.37) CCR1CCR5RAB9ACCR8NOS3
SCHEMBL862768 0.83 CCR1 (0.73) CCR1CCR5CCR8NOS3NOS1
SCHEMBL30286995 0.82 CCR1 (0.62) CCR1CCR5CCR8MAPTSMN1; SMN2
SCHEMBL529761 0.82 CCR1 (0.62) CCR1CCR5CCR8MAPTSMN1; SMN2
SCHEMBL862522 0.80 PDE3B (0.47) CCR1CCR8MAPTCYP1A2CYP2A6
SCHEMBL862524 0.80 CCR1 (0.64) CCR1CCR5CCR8CYP2A6KMT2A
Water SCHEMBL27996227 0.80 CCR1 (0.61) CCR1CCR5CCR8MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747260-A1 MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. Hoffmann-La Roche AG (CH) 2026-05-27 EP disclosed
WO-2025021666-A1 MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. HOFFMANN-LA ROCHE AG (CH) 2025-01-30 WO disclosed
WO-2023282236-A1 RARE EARTH COMPLEX 東ソー株式会社 2023-01-12 WO disclosed
US-20180212158-A1 ORGANIC LIGHT-EMITTING DIODE MATERIALS PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2018-07-26 US disclosed
EP-2880080-B1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PROD & CHEM (US) 2018-07-04 EP disclosed
US-20170244049-A1 ORGANIC LIGHT-EMITTING DIODE MATERIALS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2017-08-24 US disclosed
US-9396831-B2 Polymer compound and electronic device using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-07-19 US disclosed
US-9396831-B2 Polymer compound and electronic device using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-07-19 US disclosed
US-8753426-B2 Polymers, polymer membranes and methods of producing the same AIR PRODUCTS AND CHEMICALS, INC. (US) 2014-06-17 US disclosed
US-20140084217-A1 POLYMER COMPOUND AND ELECTRONIC DEVICE USING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-03-27 US disclosed
US-20140084217-A1 POLYMER COMPOUND AND ELECTRONIC DEVICE USING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-03-27 US disclosed
US-20140033918-A1 Polymers, Polymer Membranes And Methods Of Producing The Same AIR PRODUCTS AND CHEMICALS, INC. (US) 2014-02-06 US disclosed
US-20140033918-A1 Polymers, Polymer Membranes And Methods Of Producing The Same AIR PRODUCTS AND CHEMICALS, INC. (US) 2014-02-06 US disclosed
WO-2014022738-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2014-02-06 WO disclosed
CN-102146088-A Copper complex of phenanthroline derivative and preparation method and application thereof UNIV CAPITAL NORMAL 2011-08-10 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180212158-A1 ORGANIC LIGHT-EMITTING DIODE MATERIALS MSN, DDT, NECTIN4 CCR1 1740/4885CCR5 1259/4885RAB9A 2572/4885
US-20170244049-A1 ORGANIC LIGHT-EMITTING DIODE MATERIALS CYBA, DDT, DRD1 CCR1 3317/4885CCR5 3385/4885RAB9A 1317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.