Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2701324 | 0.89 | HTT (0.76) | HTTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL31098214 | 0.87 | HTT (0.73) | HTTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL15541786 | 0.87 | HTT (0.64) | HTTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL2699444 | 0.87 | HTT (0.69) | HTTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL14855912 | 0.85 | L3MBTL1 (0.61) | HTTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL5224838 | 0.85 | RAB9A (0.62) | HTTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL31424196 | 0.85 | RAB9A (0.62) | HTTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL17772176 | 0.85 | HTT (0.63) | HTTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2308520 | 0.85 | HTT (0.62) | HTTMEN1KMT2ATDP1RAB9A | |
| SCHEMBL4716633 | 0.85 | TDP1 (0.61) | HTTMEN1KMT2ATDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481394-A1 | THIOHYDANTOIN ANDROGEN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CANCER | Janssen Pharmaceutica N.V. (BE) | 2019-05-15 | — | — | EP | claimed |
| WO-2018009694-A1 | THIOHYDANTOIN ANDROGEN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2018-01-11 | — | — | WO | claimed |
| EP-3500259-A1 | THIOHYDANTOIN ANDROGEN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CANCER | Janssen Pharmaceutica NV (BE) | 2019-06-26 | — | — | EP | disclosed |
| WO-2018037342-A1 | THIOHYDANTOIN ANDROGEN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2018-03-01 | — | — | WO | disclosed |
| US-9056284-B2 | Chlorine resistant amides, polyamides, and membranes made from the same | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR (US) | 2015-06-16 | — | — | US | disclosed |
| US-9056284-B2 | Chlorine resistant amides, polyamides, and membranes made from the same | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR (US) | 2015-06-16 | — | — | US | disclosed |
| US-20140042082-A1 | CHLORINE RESISTANT AMIDES, POLYAMIDES, AND MEMBRANES MADE FROM THE SAME | THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR | 2014-02-13 | — | — | US | disclosed |
| US-20140042082-A1 | CHLORINE RESISTANT AMIDES, POLYAMIDES, AND MEMBRANES MADE FROM THE SAME | THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE INTERIOR | 2014-02-13 | — | — | US | disclosed |