Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 9/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16997520 | 0.81 | DAO (0.60) | KIF11DAOLMNAMAPTAURKA | |
| SCHEMBL31383911 | 0.80 | DAO (0.42) | DAOPOLBMEN1CYP1A2KMT2A | |
| SCHEMBL15079233 | 0.78 | POLB (0.53) | KIF11DAOPOLBALDH1A1 | |
| SCHEMBL1268409 | 0.73 | DAO (0.55) | DAOPOLBMEN1CYP1A2KMT2A | |
| SCHEMBL15079240 | 0.71 | RXFP1 (0.36) | DAOLMNAMAPT | |
| SCHEMBL20968807 | 0.70 | PARP1 (0.44) | DAOPOLBMEN1CYP1A2KMT2A | |
| SCHEMBL26523311 | 0.68 | KIF11 (0.53) | KIF11DAOCA2MEN1CYP1A2 | |
| SCHEMBL22928150 | 0.68 | KIF11 (0.53) | KIF11CA2MEN1CYP1A2KMT2A | |
| SCHEMBL12372609 | 0.67 | DAO (0.58) | DAOAURKAALDH1A1 | |
| SCHEMBL27022548 | 0.67 | CA2 (0.34) | CA2MAPTGABRA1GABRB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648086-B2 | 5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors | ASCEPION PHARMACEUTICALS, INC. (CN) | 2014-02-11 | — | — | US | disclosed |