Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 8/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15468354 | 0.91 | LRRK2 (0.55) | LRRK2GRM4PDE10AGRM5 | |
| SCHEMBL2408815 | 0.83 | GRM4 (0.47) | LRRK2GRM4GRM5 | |
| SCHEMBL2408814 | 0.83 | GRM4 (0.47) | LRRK2GRM4GRM5 | |
| SCHEMBL19172439 | 0.83 | GRM4 (0.47) | LRRK2GRM4GRM5 | |
| SCHEMBL15468357 | 0.82 | PDE10A (0.57) | LRRK2PDE10A | |
| SCHEMBL12319245 | 0.80 | GRM4 (0.44) | LRRK2GRM4PDE10AGRM5SYK | |
| SCHEMBL23343478 | 0.78 | ALDH1A1 (0.46) | LRRK2GRM4GRM5 | |
| SCHEMBL3675210 | 0.78 | ROCK2 (0.47) | GRM4GRM5 | |
| SCHEMBL2406830 | 0.78 | ALDH1A1 (0.46) | LRRK2GRM4GRM5 | |
| SCHEMBL2406826 | 0.78 | ALDH1A1 (0.46) | LRRK2GRM4GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648068-B2 | Heterocycloalkyl-containing thienopyrimidines for pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-11 | — | — | US | disclosed |