Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.71 |
| ▸ | PGR | P06401 | 3/20 | 0.71 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | AR | P10275 | 2/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.69 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.69 |
| ▸ | SHBG | P04278 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone Phosphoric Acid SCHEMBL13026155 | 0.95 | HIF1A (0.78) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL7868481 | 0.95 | HIF1A (0.78) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL250125 | 0.95 | HIF1A (0.78) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL3098603 | 0.94 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL31148432 | 0.94 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL19475421 | 0.94 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| SCHEMBL16170234 | 0.89 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL42271 | 0.88 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL1761098 | 0.88 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL19459282 | 0.88 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180042899-A1 | Method of Treating Transplant Rejection and Autoimmune Diseases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-15 | — | — | US | disclosed |
| US-20140050694-A1 | Method of Treating Transplant Rejection and Autoimmune Diseases | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-02-20 | — | — | US | disclosed |