Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 9/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.77 |
| ▸ | PGR | P06401 | 2/20 | 0.77 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | AR | P10275 | 1/20 | 0.77 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | SHBG | P04278 | 1/20 | 0.74 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone Phosphoric Acid SCHEMBL19459282 | 1.00 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL42271 | 1.00 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL21647387 | 0.99 | HIF1A (0.75) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL21313286 | 0.97 | HIF1A (0.81) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL6122495 | 0.95 | HIF1A (0.86) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL28230177 | 0.94 | HIF1A (0.69) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL22982268 | 0.93 | HIF1A (0.77) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL13026155 | 0.92 | HIF1A (0.78) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL7868481 | 0.92 | HIF1A (0.78) | HIF1APGRSERPINA6LMNAAR | |
| Hydrocortisone Phosphoric Acid SCHEMBL250125 | 0.92 | HIF1A (0.78) | HIF1APGRSERPINA6LMNAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 210 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1744683-B1 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE AGENTS | ALZA CORP (US) | 2016-03-16 | — | — | EP | claimed |
| US-8361022-B2 | Apparatus for transdermal delivery of parathyroid hormone agents | ALZA CORPORATION (US) | 2013-01-29 | — | — | US | claimed |
| US-20100152649-A1 | Apparatus and method for transdermal delivery of parathyroid hormone agents | ALZA CORPORATION (US) | 2010-06-17 | — | — | US | claimed |
| EP-1706176-A4 | FREQUENCY ASSISTED TRANSDERMAL AGENT DELIVERY METHOD AND SYSTEM | ALZA CORP (US) | 2008-06-25 | — | — | EP | claimed |
| EP-1686904-A4 | ULTRASOUND ASSISTED TRANSDERMAL VACCINE DELIVERY METHOD AND SYSTEM | ALZA CORP (US) | 2008-02-27 | — | — | EP | claimed |
| EP-1680178-A4 | SYSTEM AND METHOD FOR TRANSDERMAL VACCINE DELIVERY | ALZA CORP (US) | 2008-01-02 | — | — | EP | claimed |
| JP-2007530680-A | — | — | 2007-11-01 | — | — | JP | claimed |
| EP-1744683-A2 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE AGENTS | ALZA Corporation (US) | 2007-01-24 | — | — | EP | claimed |
| EP-1737434-A2 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF FENTANYL-BASED AGENTS | ALZA CORPORATION (US) | 2007-01-03 | — | — | EP | claimed |
| EP-1734993-A2 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF INFLUENZA VACCINE | ALZA CORPORATION (US) | 2006-12-27 | — | — | EP | claimed |
| US-20050112135-A1 | Ultrasound assisted transdermal vaccine delivery method and system | ALZA CORPORATION | 2005-05-26 | — | — | US | claimed |
| WO-2005044366-A2 | SYSTEM AND METHOD FOR TRANSDERMAL VACCINE DELIVERY | ALZA CORPORATION (US) | 2005-05-19 | — | — | WO | claimed |
| WO-2005042702-A2 | COMPOSITIONS OF STABILIZED DNA FOR COATING MICROPROJECTIONS | ALZA CORPORATION (US) | 2005-05-12 | — | — | WO | claimed |
| US-20050090009-A1 | Compositions of stabilized DNA for coating microprojctions | ALZA CORPORATION | 2005-04-28 | — | — | US | claimed |
| US-20050049549-A1 | Method and device for enhancing transdermal agent flux | ALZA CORPORATION | 2005-03-03 | — | — | US | claimed |
| WO-2005016441-A1 | METHOD AND DEVICE FOR ENHANCING TRANSDERMAL AGENT FLUX | ALZA CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016440-A1 | METHOD AND DEVICE FOR ENHANCING TRANSDERMAL AGENT FLUX | ALZA CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| US-20050031676-A1 | Method and device for enhancing transdermal agent flux | ALZA CORPORATION | 2005-02-10 | — | — | US | claimed |
| US-20050025778-A1 | Microprojection array immunization patch and method | ALZA CORPORATION | 2005-02-03 | — | — | US | claimed |
| WO-2005002453-A1 | MICROPROJECTION ARRAY IMMUNIZATION PATCH AND METHOD | ALZA CORPORATION (US) | 2005-01-13 | — | — | WO | claimed |