Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480417

SCHEMBL15480417

SCHEMBL15480417

O=C(CCCCCCC(=O)Nc1ccc(Br)cc1)NO

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 14/20 0.73
▸ HDAC6 Q9UBN7 13/20 0.73
▸ HDAC2 Q92769 12/20 0.73
▸ HDAC3 O15379 11/20 0.73
▸ HDAC8 Q9BY41 11/20 0.73
▸ HDAC11 Q96DB2 10/20 0.73
▸ HDAC10 Q969S8 9/20 0.73
▸ NCOR2 Q9Y618 2/20 0.73
▸ HDAC4 P56524 9/20 0.72
▸ HDAC7 Q8WUI4 9/20 0.72
▸ HDAC9 Q9UKV0 9/20 0.72
▸ HDAC5 Q9UQL6 9/20 0.72
▸ KDM4E B2RXH2 1/20 0.72
▸ BRD4 O60885 1/20 0.72
▸ NCOR1 O75376 1/20 0.72
▸ NR1I2 O75469 1/20 0.72
▸ EGFR P00533 1/20 0.72
▸ CYP3A4 P08684 1/20 0.72
▸ LTA4H P09960 1/20 0.72
▸ NR0B1 P51843 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31635263 0.93 HDAC1 (0.83) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL22479429 0.88 MEN1 (0.61) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL30446090 0.86 RAB9A (0.62) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL4654699 0.86 MEN1 (0.63) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL28801149 0.86 POLB (0.65) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL23054846 0.84 HDAC1 (0.71) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL19605418 0.84 HDAC1 (0.76) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL13524769 0.84 HDAC1 (1.00) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL19605450 0.84 HDAC1 (0.76) HDAC1HDAC6HDAC2HDAC3HDAC8
SCHEMBL11939633 0.84 HDAC1 (1.00) HDAC1HDAC6HDAC2HDAC3HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC6 10/4885HDAC2 3/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC6 10/4885HDAC2 3/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC1 2/4885HDAC6 10/4885HDAC2 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.