Sugi Predict

Sugi Predict / Compounds / SCHEMBL15480644

SCHEMBL15480644

SCHEMBL15480644

CSc1nc2cc(S(=O)(=O)N(C)c3ccc(C(=O)NO)cc3)ccc2n1C

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ HDAC6 Q9UBN7 16/20 0.44
▸ HDAC1 Q13547 6/20 0.44
▸ MEN1 O00255 1/20 0.41
▸ RECQL P46063 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ SIRT2 Q8IXJ6 1/20 0.41
▸ HDAC8 Q9BY41 4/20 0.41
▸ F2 P00734 1/20 0.41
▸ HDAC3 O15379 2/20 0.39
▸ HDAC2 Q92769 2/20 0.39
▸ BRPF1 P55201 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15480641 0.84 HDAC6 (0.45) HDAC6HDAC1MEN1RECQLKMT2A
SCHEMBL15480584 0.82 HDAC6 (0.54) HDAC6HDAC1HDAC8F2HDAC3
SCHEMBL15480626 0.77 CYP1A2 (0.46) HDAC6HDAC1MEN1KMT2ASIRT2
SCHEMBL23054939 0.74 SIRT2 (0.43) HDAC6HDAC1RECQLSIRT2HDAC8
SCHEMBL15480625 0.74 GPR55 (0.59) HDAC6MEN1KMT2ASIRT2
SCHEMBL15480643 0.73 ALDH1A1 (0.61) HDAC6HDAC1MEN1KMT2ASIRT2
SCHEMBL15480617 0.72 NPC1 (0.45) MEN1KMT2ASIRT2
SCHEMBL15480616 0.72 HDAC6 (0.55) HDAC6KMT2ASIRT2
SCHEMBL15480619 0.72 NPC1 (0.45) HDAC6HDAC1MEN1KMT2ASIRT2
SCHEMBL15480612 0.72 NPC1 (0.67) HDAC6HDAC1MEN1KMT2ASIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB (SE) 2021-03-04 — — US disclosed
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENT AB (SE) 2017-01-26 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS CERENO SCIENTIFIC AB 2014-02-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140051716-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC6 10/4885HDAC1 2/4885MEN1 4342/4885
US-20170020874-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC6 10/4885HDAC1 2/4885MEN1 4342/4885
US-20210060014-A1 COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS HDAC3, HDAC1, HDAC2 HDAC6 10/4885HDAC1 2/4885MEN1 4342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.