Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.71 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.71 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.71 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | BAZ2B | Q9UIF8 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | BPTF | Q12830 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.56 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.55 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15496579 | 0.83 | BRD4 (1.00) | BRD4BRD3CREBBPBRD7BAZ2B | |
| SCHEMBL15496562 | 0.83 | BRD4 (0.71) | BRD4BRD3CREBBPBRD7KDM4E | |
| SCHEMBL15496612 | 0.82 | BRD4 (0.69) | BRD4BRD3CREBBPBRD7KDM4E | |
| SCHEMBL15496560 | 0.82 | BRD4 (0.69) | BRD4BRD3CREBBPBRD7KDM4E | |
| SCHEMBL15499071 | 0.81 | BRD4 (0.64) | BRD4BRD3CREBBPBRD7KDM4E | |
| SCHEMBL15499078 | 0.80 | KDM4E (0.57) | BRD4BRD3CREBBPBRD7KDM4E | |
| SCHEMBL15499090 | 0.78 | ALDH1A1 (0.71) | BRD4KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL15986425 | 0.77 | KDM4E (0.70) | KDM4EALDH1A1POLBMEN1KMT2A | |
| SCHEMBL15215659 | 0.77 | POLB (0.72) | BRD4BRD3CREBBPBRD7KDM4E | |
| SCHEMBL10242038 | 0.76 | BRD4 (1.00) | BRD4BRD3CREBBPBRD7BAZ2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066410-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2014-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066410-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | NFKBIA, NFKB2, IKBKG | BRD4 23/4885BRD3 14/4885CREBBP 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.