SCHEMBL15501124

SCHEMBL15501124

N#Cc1c(N)nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccc(CCCCO)cc1

nearest known ligand 0.77

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 19/20 0.77
SLC6A3 Q01959 1/20 0.75
RET P07949 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7900475 0.97 ADORA1 (0.78) ADORA1SLC6A3RET
SCHEMBL7900477 0.89 ADORA1 (0.66) ADORA1SLC6A3RET
SCHEMBL8008750 0.88 ADORA1 (0.65) ADORA1SLC6A3RET
SCHEMBL14464171 0.86 ADORA1 (0.63) ADORA1SLC6A3
SCHEMBL1177766 0.86 ADORA1 (0.84) ADORA1SLC6A3RET
SCHEMBL13943171 0.86 ADORA1 (0.69) ADORA1SLC6A3RET
Capadenoson SCHEMBL174016 0.86 ADORA1 (1.00) ADORA1SLC6A3
SCHEMBL13879910 0.86 ADORA1 (0.61) ADORA1SLC6A3RET
SCHEMBL1072685 0.85 ADORA1 (0.70) ADORA1SLC6A3
SCHEMBL7893973 0.84 ADORA1 (0.59) ADORA1SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2185552-B1 DIPEPTOID PRODRUGS AND THE USE THEREOF BAYER IP GMBH (DE) 2014-03-12 EP disclosed