SCHEMBL7900475

SCHEMBL7900475

N#Cc1c(N)nc(SCc2csc(-c3ccc(Cl)cc3)n2)c(C#N)c1-c1ccc(CCCO)cc1

nearest known ligand 0.78

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 19/20 0.78
SLC6A3 Q01959 1/20 0.77
RET P07949 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15501124 0.97 ADORA1 (0.77) ADORA1SLC6A3RET
SCHEMBL7900477 0.92 ADORA1 (0.66) ADORA1SLC6A3RET
SCHEMBL8008750 0.91 ADORA1 (0.65) ADORA1SLC6A3RET
SCHEMBL14464171 0.89 ADORA1 (0.63) ADORA1SLC6A3
SCHEMBL13879910 0.88 ADORA1 (0.61) ADORA1SLC6A3RET
SCHEMBL1072685 0.88 ADORA1 (0.70) ADORA1SLC6A3
SCHEMBL1177766 0.87 ADORA1 (0.84) ADORA1SLC6A3RET
SCHEMBL13943171 0.87 ADORA1 (0.69) ADORA1SLC6A3RET
Capadenoson SCHEMBL174016 0.87 ADORA1 (1.00) ADORA1SLC6A3
SCHEMBL7893973 0.87 ADORA1 (0.59) ADORA1SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010086101-A1 ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-08-05 WO disclosed
EP-1765343-B1 USE OF SUBSTITUTED 2-THIO-3,5-DICYANO-4-PHENYL-6-AMINOPYRIDINES IN THE TREATMENT OF NAUSEA AND VOMITING BAYER SCHERING PHARMA AG (DE) 2009-10-28 EP disclosed
EP-1455785-B1 SUBSTITUTED 2-THIO-3,5-DICYANO-4-PHENYL-6-AMINOPYRIDINES AND THE USE OF THE SAME BAYER HEALTHCARE AG (DE) 2009-03-04 EP disclosed
WO-2009015811-A1 DIPEPTOID PRODRUGS AND THE USE THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2009-02-05 WO disclosed
WO-2009015812-A2 PRODRUGS OF 2-AMINO-6- ( { [2- (4-CHLORPHENYL) -1, 3-THIAZ0L-4-YL] METHYL}THIO) -4- [4- ( 2 -HYDROXYETHOXY) PHENYL] PYRIDIN-3, 5-DICARBONITRILE BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2009-02-05 WO disclosed
WO-2007101531-A1 USE OF ADENOSINE A1 AND/OR DUAL A1/A2B AGONISTS FOR PRODUCTION OF MEDICAMENTS FOR TREATING DISEASES BAYER HEALTHCARE AG (DE) 2007-09-13 WO disclosed
WO-2007073855-A1 USE OF ADENOSINE A1 RECEPTOR AGONISTS FOR THE PROTECTION OF RENAL CELLS AGAINST TOXIC EFFECTS CAUSED BY AMINOGLYCOSIDES DURING TREATMENT OF INFECTIOUS DISEASES BAYER HEALTHCARE AG (DE) 2007-07-05 WO disclosed
WO-2007039134-A1 COMBINATION THERAPY COMPRISING SUBSTITUTED OXAZOLIDINONES FOR THE PREVENTION AND TREATMENT OF CEREBRAL CIRCULATORY DISORDERS BAYER HEALTHCARE AG (DE) 2007-04-12 WO disclosed