Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL373788 | 0.87 | SMN1; SMN2 (0.43) | HPGDRECQLHRH3KMT2AMEN1 | |
| SCHEMBL27734031 | 0.85 | SMN1; SMN2 (0.33) | HPGDRECQLHRH3KMT2AMEN1 | |
| SCHEMBL1935995 | 0.80 | CHRM2 (0.34) | HPGDRECQLHRH3CHRM2CHRM1 | |
| SCHEMBL6952722 | 0.80 | CA1 (0.32) | CA1CA2CHRM2CHRM1CHRM3 | |
| SCHEMBL6959018 | 0.79 | CA1 (0.32) | CA1CA2CHRM2CHRM1CHRM3 | |
| SCHEMBL212033 | 0.78 | CHRM2 (0.42) | HPGDRECQLHRH3HSD17B10PTPN2 | |
| SCHEMBL6820195 | 0.78 | USP2 (0.34) | HPGDRECQLHRH3CA1CA2 | |
| SCHEMBL163922 | 0.78 | HPGD (0.60) | HPGDRECQLKMT2AHSD17B10PTPN2 | |
| SCHEMBL4046093 | 0.76 | HRH3 (0.35) | HPGDRECQLHRH3KMT2AMEN1 | |
| SCHEMBL5258386 | 0.76 | NCF1 (0.40) | HPGDRECQLKMT2AALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271405-B1 | NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK PATENT GMBH (DE) | 2013-07-24 | — | — | EP | claimed |
| EP-2313403-B1 | THIAZOLYL PIPERDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-04-08 | — | — | EP | disclosed |
| EP-2313403-A2 | THIAZOLYL PIPERDINE DERIVATIVES | Merck Patent GmbH (DE) | 2011-04-27 | — | — | EP | disclosed |
| WO-2009156041-A2 | THIAZOLYL PIPERDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-12-30 | — | — | WO | disclosed |