Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952722 | 0.90 | CA1 (0.32) | CA1CA2CHRM2CHRM1CHRM3 | |
| SCHEMBL6955137 | 0.86 | F2 (0.33) | CHRM2CHRM1CHRM3 | |
| SCHEMBL1550155 | 0.79 | HPGD (0.37) | CA1CA2CHRM2CHRM1CHRM3 | |
| SCHEMBL21797068 | 0.78 | HPGD (0.43) | — | |
| SCHEMBL18399262 | 0.78 | HPGD (0.43) | — | |
| SCHEMBL14763728 | 0.76 | CHRM2 (0.40) | CA1CA2CHRM2CHRM1CHRM3 | |
| SCHEMBL7284763 | 0.76 | CHRM2 (0.40) | CA1CA2CHRM2CHRM1CHRM3 | |
| SCHEMBL8329981 | 0.76 | CHRM2 (0.37) | CHRM2CHRM1CHRM3 | |
| SCHEMBL8329335 | 0.76 | CHRM2 (0.37) | CHRM2CHRM1CHRM3 | |
| SCHEMBL4440743 | 0.75 | CTSK (0.33) | CA1CA2CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |