Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15510127 | 0.90 | HPGD (0.40) | MAPTALDH1A1PRKD1 | |
| SCHEMBL2530156 | 0.88 | CSNK2A1 (0.42) | ABL1AKR1C3LMNAMAPTALDH1A1 | |
| SCHEMBL2531587 | 0.86 | ABL1 (0.40) | ABL1AKR1C3LMNAMAPTALDH1A1 | |
| SCHEMBL15509948 | 0.85 | ACHE (0.40) | — | |
| SCHEMBL15509446 | 0.85 | NPC1 (0.43) | LMNAALDH1A1PKMMAPK1 | |
| SCHEMBL15509655 | 0.84 | BRD4 (0.38) | ALDH1A1PRKD1MAPK1 | |
| SCHEMBL15510260 | 0.83 | PKM (0.43) | PKMMAPK1 | |
| SCHEMBL15509409 | 0.83 | SCN3A (0.43) | — | |
| SCHEMBL15510005 | 0.83 | ACHE (0.45) | LMNAALDH1A1PKM | |
| SCHEMBL15509695 | 0.82 | PARP1 (0.38) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558449-B1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-03-05 | — | — | EP | claimed |