Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 12/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 11/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 8/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15510139 | 0.97 | ENPP3 (0.42) | ENPP3ENPP1ENPP2STSKDM4E | |
| SCHEMBL15510087 | 0.87 | KDM4E (0.46) | ENPP3ENPP1ENPP2KDM4EHSD17B10 | |
| SCHEMBL15509471 | 0.87 | KDM4E (0.46) | ENPP3ENPP1KDM4EHSD17B10 | |
| SCHEMBL15509791 | 0.86 | KDM4E (0.44) | ENPP3ENPP1ENPP2KDM4EHSD17B10 | |
| SCHEMBL2530582 | 0.86 | IP6K1 (0.45) | ENPP3ENPP1KDM4EHSD17B10PTPN1 | |
| SCHEMBL15510703 | 0.85 | GAA (0.41) | HPGD | |
| SCHEMBL2531307 | 0.84 | SMN1; SMN2 (0.45) | KDM4EHSD17B10PTPN1HPGD | |
| SCHEMBL15509857 | 0.84 | KDM4E (0.42) | KDM4EHSD17B10 | |
| SCHEMBL15509510 | 0.84 | KMT2A (0.39) | KDM4EHPGD | |
| SCHEMBL15509508 | 0.83 | NPC1 (0.43) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558449-B1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-03-05 | — | — | EP | claimed |