Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 6/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15509929 | 0.91 | ACHE (0.41) | GAAACHEBCHENPSR1 | |
| SCHEMBL15509717 | 0.87 | HTT (0.43) | LMNAHTTSMN1; SMN2ACHEBCHE | |
| SCHEMBL15510139 | 0.86 | ENPP3 (0.42) | LMNATP53 | |
| SCHEMBL2533260 | 0.86 | IP6K1 (0.44) | GAAUSP2LMNAHPGDHTT | |
| SCHEMBL27905174 | 0.85 | EPHX2 (0.41) | GAALMNAHTTSMN1; SMN2ACHE | |
| SCHEMBL15510031 | 0.85 | MEN1 (0.42) | GAASMN1; SMN2ACHEBCHE | |
| SCHEMBL15510068 | 0.85 | ACHE (0.39) | ACHEBCHE | |
| SCHEMBL15510486 | 0.85 | ENPP3 (0.46) | HPGD | |
| SCHEMBL15509518 | 0.85 | ACHE (0.40) | SMN1; SMN2ACHEBCHEALDH1A1TP53 | |
| SCHEMBL15509644 | 0.85 | NPC1 (0.43) | SMN1; SMN2ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558449-B1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-03-05 | — | — | EP | claimed |