Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.42 |
| ▸ | DPP4 | P27487 | 6/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.42 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13829067 | 0.78 | DPP7 (0.56) | DPP7DPP8DPP4DPP9SLC15A1 | |
| SCHEMBL14974240 | 0.77 | METAP2 (0.48) | DPP7DPP8DPP4DPP9SLC15A1 | |
| Hydrochloric Acid SCHEMBL5218526 | 0.77 | CYP2D6 (0.39) | DPP7DPP8DPP4DPP9SLC15A1 | |
| SCHEMBL13990341 | 0.75 | HDAC7 (0.41) | DPP7DPP8DPP4DPP9SLC15A1 | |
| SCHEMBL10087537 | 0.75 | HDAC7 (0.41) | DPP7DPP8DPP4DPP9SLC15A1 | |
| SCHEMBL21661351 | 0.74 | DPP4 (0.43) | DPP7DPP8DPP4DPP9FAP | |
| SCHEMBL21034775 | 0.74 | DPP4 (0.43) | DPP7DPP8DPP4DPP9FAP | |
| SCHEMBL13523609 | 0.74 | DPP4 (0.43) | DPP7DPP8DPP4DPP9FAP | |
| SCHEMBL15700570 | 0.74 | ALDH1A1 (0.46) | DPP7DPP8DPP4DPP9FAP | |
| SCHEMBL20556002 | 0.73 | CHRM1 (0.48) | MAPK1GRIK1SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066488-A1 | Inhibitors of Memapsin 2 Cleavage for the Treatment of Alzheimer's Disease | PURDUE RESEARCH FOUNDATION (US) | 2014-03-06 | — | — | US | disclosed |
| WO-2014036105-A2 | INHIBITORS OF MEMAPSIN 2 CLEAVAGE FOR THE TREATMENT OF ALZHEIMER'S DISEASE | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2014-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066488-A1 | Inhibitors of Memapsin 2 Cleavage for the Treatment of Alzheimer's Disease | PSEN2, BACE2, PSEN1 | DPP7 527/4885DPP8 971/4885DPP4 840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.