Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2545267 | 0.88 | GPR119 (0.60) | GPR119 | |
| SCHEMBL1549998 | 0.85 | ALDH1A1 (0.41) | — | |
| SCHEMBL1550611 | 0.84 | GPR119 (0.45) | GPR119EPHX2 | |
| SCHEMBL1550677 | 0.83 | GAA (0.40) | — | |
| SCHEMBL14237663 | 0.82 | GPR119 (0.61) | GPR119 | |
| SCHEMBL2546607 | 0.80 | KMT2A (0.36) | — | |
| SCHEMBL1550384 | 0.79 | GPR119 (0.60) | GPR119 | |
| SCHEMBL14237660 | 0.79 | JAK3 (0.36) | GPR119 | |
| SCHEMBL1550698 | 0.79 | GPR119 (0.55) | GPR119 | |
| SCHEMBL1549862 | 0.78 | GPR119 (0.43) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313395-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | Bristol-Myers Squibb Company (US) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010009183-A1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-01-21 | — | — | WO | disclosed |