SCHEMBL15510866

SCHEMBL15510866

CC(C)(C)OC(=O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)CN=[N+]=[N-])C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 8/20 0.39
▸ ATM Q13315 2/20 0.38
▸ MAPT P10636 6/20 0.37
▸ NPSR1 Q6W5P4 9/20 0.37
▸ KMT2A Q03164 6/20 0.37
▸ MEN1 O00255 5/20 0.37
▸ POLB P06746 4/20 0.37
▸ FOLH1 Q04609 1/20 0.37
▸ KDM4E B2RXH2 3/20 0.35
▸ ALDH1A1 P00352 1/20 0.33
▸ PAX8 Q06710 1/20 0.33
▸ EPHX2 P34913 1/20 0.33
▸ ALB P02768 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15510867 1.00 TDP1 (0.39) TDP1ATMMAPTNPSR1KMT2A
SCHEMBL18161564 1.00 TDP1 (0.39) TDP1ATMMAPTNPSR1KMT2A
SCHEMBL15495587 0.96 TDP1 (0.37) TDP1ATMMAPTNPSR1KMT2A
SCHEMBL15498130 0.89 FOLH1 (0.52) FOLH1
SCHEMBL22342625 0.89 FOLH1 (0.52) FOLH1
SCHEMBL14682796 0.86 TDP1 (0.45) TDP1ATMMAPTNPSR1KMT2A
SCHEMBL21541230 0.86 FOLH1 (0.38) TDP1ATMMAPTNPSR1KMT2A
SCHEMBL16094006 0.86 FOLH1 (0.38) TDP1ATMMAPTNPSR1KMT2A
SCHEMBL15498145 0.85 FOLH1 (0.41) FOLH1
SCHEMBL25963705 0.84 TDP1 (0.43) TDP1ATMMAPTNPSR1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583887-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2026-03-24 — — US disclosed
US-12559521-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2026-02-24 — — US disclosed
US-20240425547-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2024-12-26 — — US disclosed
US-20240409580-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2024-12-12 — — US disclosed
US-12139554-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2024-11-12 — — US disclosed
US-12122851-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2024-10-22 — — US disclosed
US-20210032286-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2021-02-04 — — US disclosed
US-20210032286-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2021-02-04 — — US disclosed
US-20210024574-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2021-01-28 — — US disclosed
US-20210024574-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2021-01-28 — — US disclosed
US-20200377549-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2020-12-03 — — US disclosed
US-20200377549-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2020-12-03 — — US disclosed
US-20180258134-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2018-09-13 — — US disclosed
US-10011632-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2018-07-03 — — US disclosed
US-10011632-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2018-07-03 — — US disclosed
US-10011632-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2018-07-03 — — US disclosed
US-20160304555-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2016-10-20 — — US disclosed
US-20160304555-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2016-10-20 — — US disclosed
US-20160304555-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2016-10-20 — — US disclosed
US-20140065070-A1 METHODS OF PREPARING TRIAZOLE-CONTAINING RADIOIODINATED COMPOUNDS MCMASTER UNIVERSITY (CA) 2014-03-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240425547-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 TDP1 2960/4885ATM 1557/4885MAPT 1246/4885
US-20180258134-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 TDP1 2960/4885ATM 1557/4885MAPT 1246/4885
US-20240409580-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 TDP1 2960/4885ATM 1557/4885MAPT 1246/4885
US-12559521-B2 PSMA imaging agents KLK3, PSMA1, PSMA6 TDP1 3245/4885ATM 2762/4885MAPT 2115/4885
US-12139554-B2 PSMA imaging agents FOLH1, KLK3, PSMA2 TDP1 2960/4885ATM 1557/4885MAPT 1246/4885
US-20200377549-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 TDP1 2960/4885ATM 1557/4885MAPT 1246/4885
US-12583887-B2 PSMA imaging agents KLK3, PSMA3, PSMA1 TDP1 3379/4885ATM 2042/4885MAPT 1455/4885
US-20140065070-A1 METHODS OF PREPARING TRIAZOLE-CONTAINING RADIOIODINATED COMPOUNDS CYP11B1, CYP11B2, PAICS TDP1 647/4885ATM 644/4885MAPT 3523/4885
US-20210032286-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 TDP1 2960/4885ATM 1557/4885MAPT 1246/4885
US-10011632-B2 PSMA imaging agents FOLH1, KLK3, PSMA2 TDP1 2960/4885ATM 1557/4885MAPT 1246/4885
US-12122851-B2 PSMA imaging agents FOLH1, KLK3, PSMA2 TDP1 2960/4885ATM 1557/4885MAPT 1246/4885
US-20210024574-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 TDP1 2960/4885ATM 1557/4885MAPT 1246/4885
US-20160304555-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 TDP1 2960/4885ATM 1557/4885MAPT 1246/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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