Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.51 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20496871 | 0.83 | LMNA (0.54) | GAAALDH1A1LMNAALOX12MAPT | |
| SCHEMBL5528698 | 0.83 | PTPN7 (0.50) | GAAALDH1A1LMNAALOX12MAPT | |
| SCHEMBL8178554 | 0.80 | ANPEP (0.54) | LMNAATG4BSRC | |
| SCHEMBL4872149 | 0.79 | PTPN7 (0.53) | GAAALDH1A1LMNAALOX12MAPT | |
| SCHEMBL7655034 | 0.79 | HDAC1 (0.65) | GAAALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL15682780 | 0.79 | SRC (0.52) | ALDH1A1KMT2ASRC | |
| SCHEMBL457957 | 0.78 | GAA (1.00) | GAAALDH1A1LMNAALOX12MAPT | |
| SCHEMBL10721079 | 0.77 | LMNA (0.47) | GAAALDH1A1LMNAALOX12MAPT | |
| SCHEMBL1558245 | 0.76 | SMN1; SMN2 (0.65) | GAAALDH1A1LMNAMAPTPKM | |
| SCHEMBL31612206 | 0.76 | CYP3A4 (0.59) | LMNAMAPTPKMIDO1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313380-B1 | OXADIAZOLE DERIVATIVES FOR TREATING DIABETES | MERCK PATENT GMBH (DE) | 2013-12-11 | — | — | EP | disclosed |
| US-8466170-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2013-06-18 | — | — | US | disclosed |
| US-8466170-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2013-06-18 | — | — | US | disclosed |
| US-8377975-B2 | Oxadiazole derivatives for the treatment of diabetes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-02-19 | — | — | US | disclosed |
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-07 | — | — | US | disclosed |
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-07 | — | — | US | disclosed |
| US-20110139654-A1 | OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | MERCK PATENT GESELLSCHAFT (DE) | 2011-06-16 | — | — | US | disclosed |
| EP-2313380-A1 | OXADIAZOLE DERIVATIVES FOR TREATING DIABETES | Merck Patent GmbH (DE) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010020308-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010020305-A1 | OXADIAZOLE DERIVATIVES FOR TREATING DIABETES | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | JAK3, AZI2, MYLK2 | GAA 2042/4885ALDH1A1 3178/4885LMNA 1025/4885 |
| US-20110139654-A1 | OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | PFKL, RXFP3, OXA1L | GAA 1566/4885ALDH1A1 2507/4885LMNA 3264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.