SCHEMBL457957

SCHEMBL457957

NNC(=S)NCc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 5/20 1.00
ALDH1A1 P00352 5/20 0.76
ALOX12 P18054 4/20 0.76
HPGD P15428 2/20 0.76
MAPT P10636 3/20 0.73
MEN1 O00255 1/20 0.73
POLB P06746 1/20 0.73
KMT2A Q03164 1/20 0.73
LMNA P02545 2/20 0.67
TAAR1 Q96RJ0 1/20 0.67
PKM P14618 1/20 0.66
MAOA P21397 1/20 0.63
MAOB P27338 1/20 0.63
PLA2G1B P04054 1/20 0.61
ATG4B Q9Y4P1 1/20 0.61
ALPL P05186 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
MAPK1 P28482 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
CA12 O43570 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1275902 0.87 ALOX12 (1.00) GAAALDH1A1ALOX12HPGDMAPT
SCHEMBL27920286 0.84 GAA (0.72) GAAALDH1A1ALOX12HPGDMAPT
SCHEMBL7408053 0.82 GAA (0.69) GAAALDH1A1ALOX12HPGDMAPT
SCHEMBL1968541 0.80 LMNA (1.00) GAAALDH1A1ALOX12HPGDMAPT
SCHEMBL3059505 0.80 ALDH1A1 (0.70) GAAALDH1A1ALOX12HPGDMAPT
SCHEMBL17794373 0.80 GAA (0.67) GAAALDH1A1ALOX12HPGDMAPT
SCHEMBL1396191 0.79 ALOX12 (0.76) GAAALDH1A1ALOX12HPGDMAPT
SCHEMBL29220674 0.79 ALOX12 (0.76) GAAALDH1A1ALOX12HPGDMAPT
Bromide SCHEMBL25440153 0.79 GAA (0.65) GAAALDH1A1ALOX12HPGDMAPT
SCHEMBL15236141 0.79 GAA (0.65) GAAALDH1A1ALOX12HPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122060238-A Polyethylene composite packaging material and preparation method thereof 惠州市道科包装材料有限公司 2026-05-19 CN claimed
CN-115463644-B Polyacrylonitrile mercury ion adsorption resin and preparation method and application thereof 中国石油化工股份有限公司 2023-12-08 CN claimed
CN-115463644-A Polyacrylonitrile mercury ion adsorption resin and preparation method and application thereof 中国石油化工股份有限公司 2022-12-13 CN claimed
CN-111217732-B Lysosome-targeted fluorescent metal iridium dimer and preparation method and application thereof 曲阜师范大学 2021-09-24 CN claimed
WO-2016111658-A1 SYNTHESIS OF THIOSEMICARBAZONE DERIVATIVES COMPRISING SULPHONAMIDE GROUP WITH POTENTIAL ANTICONVULSANT ACTIVITY IYIDOGAN AYSEGUL (TR) 2016-07-14 WO claimed
CN-122060238-A Polyethylene composite packaging material and preparation method thereof 惠州市道科包装材料有限公司 2026-05-19 CN disclosed
CN-120005249-A Self-adaptive light-adjusting temperature-controlling polyurethane protective film and preparation method thereof 南通通易航天科技股份有限公司 2025-05-16 CN disclosed
CN-119570093-A Self-adaptive light-adjusting temperature-controlling polyurethane protective film and preparation method thereof 南通通易航天科技股份有限公司 2025-03-07 CN disclosed
WO-2025046420-A1 COMPOUND TARGETING EGR-1 AND USE THEREOF FOR TREATMENT OF ATOPIC DERMATITIS 주식회사 아제라메디 2025-03-06 WO disclosed
CN-115463644-B Polyacrylonitrile mercury ion adsorption resin and preparation method and application thereof 中国石油化工股份有限公司 2023-12-08 CN disclosed
EP-3717475-B1 KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE ICAHN SCHOOL MED MOUNT SINAI (US) 2023-06-07 EP disclosed
US-11547712-B2 Kinase inhibitor compounds and compositions and methods of use ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2023-01-10 US disclosed
EP-0107995-A1 7-Oxabicycloheptane substituted amino prostaglandin analogs E.R. Squibb & Sons, Inc. (US) 1984-05-09 EP disclosed
US-4347359-A CEPHALOSPORIN INTERMEDIATES RHONE-POULENC INDUSTRIES (FR) 1982-08-31 US disclosed
WO-1982000142-A1 PROSTAGLANDINS JONES R 1982-01-21 WO disclosed
EP-0043292-A2 Prostaglandins NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1982-01-06 EP disclosed
US-4307116-A BACTERICIDES RHONE-POULENC INDUSTRIES (FR) 1981-12-22 US disclosed
US-4304568-A Minimizing ozone fading in dyed polyamides by treating same with substituted piperidine thioureas AKZONA INCORPORATED (US) 1981-12-08 US disclosed
US-4182866-A CEPHALOSPORINS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1980-01-08 US disclosed
US-3940408-A CORROSION INHIBITORS IN LUBRICANTS TEXACO INC. (US) 1976-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11547712-B2 Kinase inhibitor compounds and compositions and methods of use MAP3K20, MAP3K1, PACSIN2 GAA 1046/4885ALDH1A1 4750/4885ALOX12 3880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.