Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20172538 | 0.82 | DGAT1 (0.34) | DGAT1ALDH1A1 | |
| SCHEMBL5398088 | 0.81 | PRSS1 (0.33) | PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL24780623 | 0.81 | DGAT1 (0.46) | DGAT1PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL16057010 | 0.80 | DGAT1 (0.39) | DGAT1TSHRKCNN4ALDH1A1 | |
| SCHEMBL12798162 | 0.79 | CYP4F2 (0.48) | TSHRALDH1A1 | |
| SCHEMBL16750337 | 0.78 | DGAT1 (0.38) | DGAT1PRSS1CTSGCTRB1CMA1 | |
| Hydrochloric Acid SCHEMBL22070617 | 0.78 | CYP4F2 (0.47) | TSHRALDH1A1 | |
| SCHEMBL18843323 | 0.76 | DGAT1 (0.37) | DGAT1 | |
| SCHEMBL21561597 | 0.76 | DGAT1 (0.37) | DGAT1PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL31580967 | 0.76 | DGAT1 (0.37) | DGAT1PRSS1CTSGCTRB1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906534-B1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | GRUENENTHAL GMBH (DE) | 2016-12-07 | — | — | EP | disclosed |
| US-9302988-B2 | Fluoromethyl-substituted pyrrole carboxamides | Grünenthal GmbH (DE) | 2016-04-05 | — | — | US | disclosed |
| EP-2906534-A1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | Grünenthal GmbH (DE) | 2015-08-19 | — | — | EP | disclosed |
| CN-104755459-A | Fluoromethyl-substituted pyrrolecarboxamides | GRUENENTHAL CHEMIE | 2015-07-01 | — | — | CN | disclosed |
| WO-2014032801-A1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | Grünenthal GmbH (DE) | 2014-03-06 | — | — | WO | disclosed |
| US-20140066426-A1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | GRUENENTHAL GMBH (DE) | 2014-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066426-A1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | TRPV1, CACNA1B, CACNA1G | DGAT1 3206/4885PRSS1 2697/4885CTSG 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.