SCHEMBL15511580

SCHEMBL15511580

CS(=O)(=O)c1ccc(OC[C@@H]2CC[C@@H](N3CCN(C(=O)O)CC3)C(F)(F)C2)c(F)c1

nearest known ligand 0.52

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 7/20 0.52
KCNH2 Q12809 2/20 0.46
GPR119 Q8TDV5 7/20 0.45
BRD4 O60885 5/20 0.42
CYP2C9 P11712 1/20 0.37
SCN9A Q15858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15512353 0.89 GPR119 (0.59) SLC6A9KCNH2GPR119SCN9A
SCHEMBL15511253 0.89 GPR119 (0.59) SLC6A9KCNH2GPR119SCN9A
SCHEMBL15495865 0.89 GPR119 (0.59) SLC6A9KCNH2GPR119SCN9A
SCHEMBL15511762 0.85 SLC6A9 (0.59) SLC6A9KCNH2GPR119BRD4
SCHEMBL15511763 0.85 SLC6A9 (0.59) SLC6A9KCNH2GPR119BRD4
SCHEMBL15511723 0.81 SLC6A9 (0.53) SLC6A9KCNH2GPR119BRD4CYP2C9
SCHEMBL13733784 0.81 SLC6A9 (0.53) SLC6A9KCNH2GPR119BRD4CYP2C9
SCHEMBL15511957 0.81 SLC6A9 (0.55) SLC6A9KCNH2GPR119BRD4
SCHEMBL15511110 0.81 SLC6A9 (0.53) SLC6A9KCNH2GPR119BRD4CYP2C9
SCHEMBL15518261 0.81 SLC6A9 (0.53) SLC6A9KCNH2GPR119BRD4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140066369-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-03-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140066369-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GLP1R, SLC5A2 SLC6A9 91/4885KCNH2 1221/4885GPR119 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.