Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HK1 | P19367 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15512357 | 0.96 | PTGDR2 (0.39) | PTGDR2MAPTALDH1A1LMNAHK1 | |
| SCHEMBL15512880 | 0.95 | POLB (0.41) | PTGDR2MAPTTP53POLBHASPIN | |
| SCHEMBL15513490 | 0.92 | PTGDR2 (0.40) | PTGDR2ALDH1A1HK1HKDC1TP53 | |
| SCHEMBL15512392 | 0.88 | PTGDR2 (0.40) | PTGDR2ALDH1A1HK1HKDC1HSD17B10 | |
| SCHEMBL15512702 | 0.88 | PTGDR2 (0.40) | PTGDR2TP53PTGDRPTGIRPOLB | |
| SCHEMBL3277171 | 0.87 | TP53 (0.48) | PTGDR2MAPTTP53POLB | |
| SCHEMBL15512990 | 0.87 | PTGDR2 (0.41) | PTGDR2PTGDRPTGIR | |
| SCHEMBL15513159 | 0.87 | MEN1 (0.40) | PTGDR2MAPTALDH1A1HK1HKDC1 | |
| SCHEMBL15512537 | 0.85 | PER2 (0.44) | PTGDR2PTGDRPTGIR | |
| SCHEMBL15513295 | 0.84 | PTGDR2 (0.39) | PTGDR2TP53PTGDRPTGIRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966134-B1 | NOVEL FUSED PYRROLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-03-12 | — | — | EP | claimed |