Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | INMT | O95050 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL3275476 | 0.93 | KMT2A (0.49) | KMT2ARAB9ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL10513 | 0.93 | PIK3CD (0.52) | KMT2ARAB9ATSHRSMN1; SMN2NPC1 | |
| Ammonia Solution, Strong SCHEMBL28542846 | 0.91 | PIK3CD (0.50) | KMT2ARAB9ATSHRSMN1; SMN2NPC1 | |
| Ethylene Glycol SCHEMBL28917599 | 0.89 | KMT2A (0.47) | KMT2ARAB9ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL8654445 | 0.89 | PIK3CD (0.48) | KMT2ARAB9ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL1527589 | 0.87 | RAB9A (0.46) | KMT2ARAB9ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL161958 | 0.87 | ALOX5 (0.50) | KMT2ARAB9ATSHRSMN1; SMN2PIK3CD | |
| SCHEMBL27679377 | 0.86 | KMT2A (0.49) | KMT2ARAB9ASMN1; SMN2NPC1PIK3CD | |
| SCHEMBL6575811 | 0.85 | ALOX5 (0.53) | KMT2ARAB9APIK3CDMEN1 | |
| SCHEMBL705126 | 0.85 | ALOX5 (0.53) | KMT2ARAB9APIK3CDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014037109-A1 | METHOD FOR PRODUCING N-SUBSTITUTED PYRROLIDONECARBOXYLIC ESTERS | CLARIANT INTERNATIONAL LTD (CH) | 2014-03-13 | — | — | WO | disclosed |