Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.52 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.52 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 4/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | ROS1 | P08922 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26260191 | 0.87 | CYP11B2 (0.52) | PRKCZCYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL444504 | 0.83 | PRKCZ (0.63) | PRKCZCYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL17691836 | 0.82 | PRKCZ (0.56) | PRKCZCYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL18891280 | 0.82 | CYP11B1 (0.69) | PRKCZCYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL26260210 | 0.81 | CYP11B2 (0.50) | PRKCZCYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL6355545 | 0.80 | CYP11B2 (0.61) | PRKCZCYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL18260193 | 0.79 | CYP11B2 (0.66) | CYP11B2CYP11B1CYP19A1CYP17A1CYP2A6 | |
| SCHEMBL23555375 | 0.78 | PRKCZ (0.58) | PRKCZCYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL7284233 | 0.78 | ESR2 (0.61) | PRKCZCYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL28933997 | 0.78 | CYP11B1 (0.59) | PRKCZCYP11B2CYP11B1CYP19A1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892890-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | Cancer Research Technology Ltd (GB) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014037751-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2014-03-13 | — | — | WO | disclosed |