⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707183 | 0.94 | CYP2B6 (0.32) | — | |
| SCHEMBL19520207 | 0.92 | CYP2B6 (0.35) | — | |
| SCHEMBL13860177 | 0.92 | CYP2B6 (0.35) | — | |
| SCHEMBL15515320 | 0.81 | — | — | |
| SCHEMBL20416441 | 0.80 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL1266718 | 0.77 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL20399278 | 0.74 | CHRM3 (0.30) | — | |
| SCHEMBL15515285 | 0.74 | ALDH1A1 (0.40) | — | |
| SCHEMBL15515185 | 0.74 | HSD11B1 (0.34) | — | |
| SCHEMBL18345253 | 0.72 | CYP1A2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181567-B9 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC (US) | 2025-09-24 | — | — | EP | disclosed |
| US-20240174676-A1 | Pyrazolopyrimidine compounds as kinase Inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2024-05-30 | — | — | US | disclosed |
| CN-110483521-B | Reversible covalent Bruton's tyrosine kinase inhibitor, pharmaceutical composition and application thereof | 杭州和正医药有限公司 | 2022-06-07 | — | — | CN | disclosed |
| US-20220073522-A1 | Substituted Pyrazolo[3,4-d]Pyrimidines as Kinase Inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2022-03-10 | — | — | US | disclosed |
| US-11040980-B2 | Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2021-06-22 | — | — | US | disclosed |
| US-20200190092-A1 | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINES AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2020-06-18 | — | — | US | disclosed |
| EP-3181567-B1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC (US) | 2019-03-20 | — | — | EP | disclosed |
| US-20180327413-A1 | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINES AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2018-11-15 | — | — | US | disclosed |
| US-9994576-B2 | Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2018-06-12 | — | — | US | disclosed |
| EP-3181567-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA, INC. (US) | 2017-06-21 | — | — | EP | disclosed |
| US-20160251358-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2016-09-01 | — | — | US | disclosed |
| US-9266895-B2 | Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2016-02-23 | — | — | US | disclosed |
| EP-2892900-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | Principia Biopharma Inc. (US) | 2015-07-15 | — | — | EP | disclosed |
| US-20150094295-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. | 2015-04-02 | — | — | US | disclosed |
| US-8940744-B2 | Pyrazolopyrimidine compounds as kinase inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2015-01-27 | — | — | US | disclosed |
| US-20140364410-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. | 2014-12-11 | — | — | US | disclosed |
| WO-2014039899-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2014-03-13 | — | — | WO | disclosed |