Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.54 |
| ▸ | MTOR | P42345 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 4/20 | 0.52 |
| ▸ | CASP7 | P55210 | 4/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409601 | 1.00 | PIK3CA (0.54) | PIK3CAMTORALDH1A1CYP1A2KDM4E | |
| SCHEMBL21722965 | 0.83 | KCNH2 (0.50) | PIK3CAMTORALDH1A1KDM4ECNR2 | |
| SCHEMBL30775408 | 0.82 | KDM4E (0.61) | PIK3CAMTORALDH1A1KDM4ETSHR | |
| SCHEMBL6787637 | 0.80 | HTR7 (0.54) | ALDH1A1CYP1A2KDM4EHPGDCYP2C19 | |
| SCHEMBL4774311 | 0.80 | CASP1 (0.53) | PIK3CAMTORALDH1A1CYP1A2KDM4E | |
| Hydrochloric Acid SCHEMBL20293632 | 0.79 | HTR7 (0.52) | ALDH1A1CYP1A2KDM4EHPGDCYP2C19 | |
| Hydrochloric Acid SCHEMBL6786943 | 0.79 | HTR7 (0.52) | ALDH1A1CYP1A2KDM4EHPGDCYP2C19 | |
| SCHEMBL18151466 | 0.79 | PIK3CA (0.71) | PIK3CAMTORCNR2PIK3R1POLB | |
| SCHEMBL1742764 | 0.76 | OGA (0.46) | PIK3CAMTORCYP1A2KDM4EPIK3CG | |
| SCHEMBL22279054 | 0.76 | KDM4E (0.57) | ALDH1A1CYP1A2KDM4EHPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043653-B2 | Efficient delivery of therapeutic molecules to cells of the inner ear | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2024-07-23 | — | — | US | disclosed |
| US-11963968-B2 | Treatment of hearing loss | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2024-04-23 | — | — | US | disclosed |
| US-20240100079-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS IN THE INNER EAR OF ADULT MAMMALS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-03-28 | — | — | US | disclosed |
| EP-4288066-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS IN THE INNER EAR OF ADULT MAMMALS | Massachusetts Eye and Ear Infirmary (US) | 2023-12-13 | — | — | EP | disclosed |
| US-20230277574-A1 | TREATMENT OF HEARING LOSS | MASSACHUSETTS EYE AND EAR INFIRMARY | 2023-09-07 | — | — | US | disclosed |
| US-11590152-B2 | Treatment of hearing loss | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2023-02-28 | — | — | US | disclosed |
| US-20220281941-A1 | EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2022-09-08 | — | — | US | disclosed |
| US-11370823-B2 | Efficient delivery of therapeutic molecules to cells of the inner ear | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2022-06-28 | — | — | US | disclosed |
| EP-3212773-B1 | EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2021-09-15 | — | — | EP | disclosed |
| US-20210030775-A1 | TREATMENT OF HEARING LOSS | MASSACHUSETTS EYE AND EAR INFIRMARY | 2021-02-04 | — | — | US | disclosed |
| EP-3743057-A1 | TREATMENT OF HEARING LOSS | Massachusetts Eye & Ear Infirmary (US) | 2020-12-02 | — | — | EP | disclosed |
| US-20200338160-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2020-10-29 | — | — | US | disclosed |
| WO-2019148067-A1 | TREATMENT OF HEARING LOSS | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2019-08-01 | — | — | WO | disclosed |
| EP-2892523-B1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2019-05-01 | — | — | EP | disclosed |
| US-20170327557-A1 | Efficient delivery of therapeutic molecules to cells of the inner ear | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-11-16 | — | — | US | disclosed |
| EP-3212773-A1 | EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR | Massachusetts Eye & Ear Infirmary (US) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016069906-A1 | EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2016-05-06 | — | — | WO | disclosed |
| US-20150209406-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2015-07-30 | — | — | US | disclosed |
| EP-2892523-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | Massachusetts Eye & Ear Infirmary (US) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014039908-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2014-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11370823-B2 | Efficient delivery of therapeutic molecules to cells of the inner ear | HES1, NOTCH1, NOTCH2 | PIK3CA 4062/4885MTOR 3441/4885ALDH1A1 1081/4885 |
| US-20170327557-A1 | Efficient delivery of therapeutic molecules to cells of the inner ear | HES1, NOTCH1, NOTCH2 | PIK3CA 4062/4885MTOR 3441/4885ALDH1A1 1081/4885 |
| US-20220281941-A1 | EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR | HES1, NOTCH1, NOTCH2 | PIK3CA 4062/4885MTOR 3441/4885ALDH1A1 1081/4885 |
| US-11590152-B2 | Treatment of hearing loss | HES1, NOTCH1, NOTCH4 | PIK3CA 240/4885MTOR 6/4885ALDH1A1 2645/4885 |
| US-20150209406-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | HES1, NOTCH1, NOTCH4 | PIK3CA 1831/4885MTOR 713/4885ALDH1A1 2115/4885 |
| US-20200338160-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | HES1, NOTCH1, NOTCH4 | PIK3CA 1723/4885MTOR 683/4885ALDH1A1 2172/4885 |
| US-20210030775-A1 | TREATMENT OF HEARING LOSS | HES1, NOTCH1, NOTCH4 | PIK3CA 240/4885MTOR 6/4885ALDH1A1 2645/4885 |
| US-20230277574-A1 | TREATMENT OF HEARING LOSS | HES1, NOTCH1, NOTCH4 | PIK3CA 240/4885MTOR 6/4885ALDH1A1 2645/4885 |
| US-12043653-B2 | Efficient delivery of therapeutic molecules to cells of the inner ear | HES1, NOTCH1, NOTCH2 | PIK3CA 4062/4885MTOR 3441/4885ALDH1A1 1081/4885 |
| US-11963968-B2 | Treatment of hearing loss | HES1, NOTCH1, NOTCH4 | PIK3CA 240/4885MTOR 6/4885ALDH1A1 2645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.