Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.47 |
| ▸ | TERT | O14746 | 3/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | S100B | P04271 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1602312 | 0.98 | TERT (0.47) | PHGDHTERTCYP2A6DYRK1ADRD2 | |
| SCHEMBL1601529 | 0.86 | MAPT (0.50) | PHGDHDRD2DRD3KCNH2MEN1 | |
| SCHEMBL29509780 | 0.84 | DYRK1A (0.58) | PHGDHDYRK1AHTT | |
| SCHEMBL2548093 | 0.84 | DYRK1A (0.58) | PHGDHDYRK1AHTT | |
| SCHEMBL17543405 | 0.83 | PHGDH (0.44) | PHGDHCYP2A6DYRK1ADRD2DRD3 | |
| SCHEMBL17543425 | 0.80 | PHGDH (0.45) | PHGDHCYP2A6DYRK1ADRD2DRD3 | |
| SCHEMBL17543417 | 0.79 | LGMN (0.49) | PHGDHCYP2A6DYRK1ADRD2DRD3 | |
| SCHEMBL2544271 | 0.77 | PHGDH (0.38) | PHGDHDYRK1ADRD2DRD3KCNH2 | |
| SCHEMBL2544274 | 0.77 | PHGDH (0.42) | PHGDHCYP2A6DYRK1ADRD2DRD3 | |
| SCHEMBL28841948 | 0.76 | BTK (0.36) | PHGDHDYRK1ADRD2DRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892892-A1 | IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR!THE TREATMENT OF CANCER | Janssen Pharmaceutica N.V. (BE) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014039769-A1 | IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR|THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-13 | — | — | WO | disclosed |