Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15505733 | 1.00 | HDAC1 (0.41) | HDAC1AVPR1AESR2NR1H2OXTR | |
| SCHEMBL15515468 | 1.00 | HDAC1 (0.41) | HDAC1AVPR1AESR2NR1H2OXTR | |
| SCHEMBL29949095 | 1.00 | HDAC1 (0.41) | HDAC1AVPR1AESR2NR1H2OXTR | |
| SCHEMBL29948788 | 0.88 | HDAC1 (0.43) | HDAC1AVPR1AESR2NR1H2OXTR | |
| SCHEMBL15505675 | 0.88 | HDAC1 (0.43) | HDAC1AVPR1AESR2NR1H2OXTR | |
| SCHEMBL20745007 | 0.83 | KMT2A (0.35) | ALDH1A1KMT2AL3MBTL1KDM4E | |
| SCHEMBL16864998 | 0.82 | AVPR1A (0.40) | HDAC1AVPR1AESR2NR1H2DDB1 | |
| SCHEMBL15508170 | 0.81 | NR1H2 (0.38) | HDAC1AVPR1ANR1H2OXTRACACB | |
| SCHEMBL15515485 | 0.81 | NR1H2 (0.40) | HDAC1AVPR1AESR2NR1H2OXTR | |
| SCHEMBL15508174 | 0.81 | NR1H2 (0.40) | HDAC1AVPR1AESR2NR1H2OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260070879-A1 | ISOXAZOLINE DERIVATIVES | ELANCO TIERGESUNDHEIT AG (CH) | 2026-03-12 | — | — | US | disclosed |
| US-12497370-B2 | Isoxazoline derivatives | ELANCO TIERGESUNDHEIT AG (CH) | 2025-12-16 | — | — | US | disclosed |
| US-20210188789-A1 | ISOXAZOLINE DERIVATIVES | ELANCO TIERGESUNDHEIT AG | 2021-06-24 | — | — | US | disclosed |
| WO-2021127188-A1 | ISOXAZOLINE DERIVATIVES AS PESTICIDES | ELANCO TIERGESUNDHEIT AG (CH) | 2021-06-24 | — | — | WO | disclosed |
| US-9221835-B2 | Spirocyclic derivatives as antiparasitic agents | ZOETIS SERVICES LLC (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150210710-A1 | SPIROCYCLIC DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2015-07-30 | — | — | US | disclosed |
| EP-2892902-A1 | SPIROCYCLIC DERIVATIVES AS ANTIPARASITIC AGENTS | Zoetis LLC (US) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014039489-A1 | SPIROCYCLIC DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS LLC (US) | 2014-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12497370-B2 | Isoxazoline derivatives | CYP3A7, CYP4X1, CYP2A7 | HDAC1 359/4885AVPR1A 1048/4885ESR2 2823/4885 |
| US-20260070879-A1 | ISOXAZOLINE DERIVATIVES | CHRM1, CBR3, AFF1 | HDAC1 453/4885AVPR1A 411/4885ESR2 1345/4885 |
| US-20150210710-A1 | SPIROCYCLIC DERIVATIVES AS ANTIPARASITIC AGENTS | AVPR1A, AVPR1B, AVPR2 | HDAC1 365/4885AVPR1A 1/4885ESR2 377/4885 |
| US-20210188789-A1 | ISOXAZOLINE DERIVATIVES | CYP3A7, CYP4X1, SIRT7 | HDAC1 377/4885AVPR1A 891/4885ESR2 2743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.