Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 5/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.75 |
| ▸ | PGR | P06401 | 5/20 | 0.75 |
| ▸ | SERPINA6 | P08185 | 5/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.75 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | SHBG | P04278 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.75 |
| ▸ | AR | P10275 | 2/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone SCHEMBL11710056 | 0.94 | HSD17B10 (0.76) | HSD17B10HIF1ANR3C1PGRSERPINA6 | |
| Meprednisone SCHEMBL9746961 | 0.93 | HSD17B10 (0.66) | HSD17B10HIF1ANR3C1PGRSERPINA6 | |
| Prednisolone SCHEMBL3884401 | 0.92 | HIF1A (0.85) | HSD17B10HIF1ANR3C1PGRSERPINA6 | |
| Prednisone SCHEMBL992150 | 0.92 | HIF1A (0.85) | HSD17B10HIF1ANR3C1PGRSERPINA6 | |
| Cortisone SCHEMBL442505 | 0.91 | HIF1A (0.85) | HSD17B10HIF1ANR3C1PGRSERPINA6 | |
| Cortisone Acetate SCHEMBL17966400 | 0.88 | HIF1A (0.74) | HSD17B10HIF1ANR3C1PGRSERPINA6 | |
| Prednisolone SCHEMBL15949914 | 0.88 | HIF1A (0.79) | HSD17B10HIF1ANR3C1PGRSERPINA6 | |
| Prednisolone SCHEMBL5532542 | 0.88 | HIF1A (0.79) | HSD17B10HIF1ANR3C1PGRSERPINA6 | |
| Prednisone SCHEMBL23974933 | 0.86 | HSD17B10 (1.00) | HSD17B10HIF1ANR3C1PGRSERPINA6 | |
| Prednisone SCHEMBL8262569 | 0.86 | HSD17B10 (1.00) | HSD17B10HIF1ANR3C1PGRSERPINA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230321434-A1 | SYSTEMS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | P TECH, LLC | 2023-10-12 | — | — | US | disclosed |
| US-11607541-B2 | Systems and methods for delivery of therapeutic agents | P TECH, LLC (US) | 2023-03-21 | — | — | US | disclosed |
| US-20200316375-A1 | SYSTEMS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | P TECH, LLC | 2020-10-08 | — | — | US | disclosed |
| US-10561838-B2 | Systems and methods for delivery of therapeutic agents | P TECH, LLC (US) | 2020-02-18 | — | — | US | disclosed |
| US-20170252556-A1 | SYSTEMS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS | P TECH, LLC (US) | 2017-09-07 | — | — | US | disclosed |
| EP-2893002-A1 | METHODS OF EXPANDING AND ASSESSING B CELLS AND USING EXPANDED B CELLS TO TREAT DISEASE | Duke University (US) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014039804-A1 | METHODS OF EXPANDING AND ASSESSING B CELLS AND USING EXPANDED B CELLS TO TREAT DISEASE | DUKE UNIVERSITY (US) | 2014-03-13 | — | — | WO | disclosed |