Sugi Predict

Sugi Predict / Compounds / Prednisolone

Prednisolone

Prednisolone

SCHEMBL3884401

C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Prednisolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 5/20 0.85
▸ HIF1A Q16665 13/20 0.85
▸ HSD17B10 Q99714 7/20 0.85
▸ CYP3A4 P08684 6/20 0.85
▸ PGR P06401 5/20 0.85
▸ CYP2C19 P33261 4/20 0.85
▸ SERPINA6 P08185 4/20 0.85
▸ NR3C2 P08235 2/20 0.85
▸ AR P10275 2/20 0.85
▸ ABCB11 O95342 2/20 0.85
▸ TNF P01375 1/20 0.85
▸ IL6 P05231 1/20 0.85
▸ GLUL P15104 1/20 0.85
▸ ADAM17 P78536 1/20 0.85
▸ GPBAR1 Q8TDU6 1/20 0.85
▸ SMN1; SMN2 Q16637 3/20 0.83
▸ KMT2A Q03164 2/20 0.83
▸ SHBG P04278 2/20 0.83
▸ MAPT P10636 1/20 0.83
▸ NFKB1 P19838 1/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Prednisolone SCHEMBL5532542 0.96 HIF1A (0.79) HIF1AHSD17B10CYP3A4NR3C1PGR
Prednisolone SCHEMBL15949914 0.96 HIF1A (0.79) HIF1AHSD17B10CYP3A4NR3C1PGR
SCHEMBL16018303 0.93 HIF1A (0.72) HIF1AHSD17B10CYP3A4NR3C1PGR
Prednisolone SCHEMBL4449434 0.92 NR3C1 (1.00) HIF1AHSD17B10CYP3A4NR3C1PGR
Prednisolone SCHEMBL2737385 0.92 NR3C1 (1.00) HIF1AHSD17B10CYP3A4NR3C1PGR
Prednisolone SCHEMBL23863778 0.92 NR3C1 (1.00) HIF1AHSD17B10CYP3A4NR3C1PGR
Prednisolone SCHEMBL12396679 0.92 NR3C1 (1.00) HIF1AHSD17B10CYP3A4NR3C1PGR
Prednisolone SCHEMBL765329 0.92 NR3C1 (1.00) HIF1AHSD17B10CYP3A4NR3C1PGR
Prednisolone SCHEMBL13044469 0.92 NR3C1 (1.00) HIF1AHSD17B10CYP3A4NR3C1PGR
Prednisolone SCHEMBL11413677 0.92 NR3C1 (1.00) HIF1AHSD17B10CYP3A4NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0334853-B1 SOFT STEROIDS HAVING ANTI-INFLAMMATORY ACTIVITY BODOR, Nicholas S. (US) 1993-06-09 — — EP claimed
CN-114007667-B Kit for cleaning intestinal anastomosis in situ 赛菲健康公司 2023-08-25 — — CN disclosed
EP-3986503-A1 KIT FOR WASHING AN INTESTINAL ANASTOMOSIS IN SITU Safeheal (FR) 2022-04-27 — — EP disclosed
CN-114007667-A Kit for cleaning an intestinal anastomosis in situ 赛菲健康公司 2022-02-01 — — CN disclosed
EP-2107909-A2 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LIVER DISORDERS IDENIX Pharmaceuticals, Inc. (US) 2009-10-14 — — EP disclosed
WO-2008082602-A2 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LIVER DISORDERS IDENIX PHARMACEUTICALS, INC. (US) 2008-07-10 — — WO disclosed
CN-100358527-C Preparation containing amino acids and riboflavin for reducing toxic and side effects of cytotoxic chemotherapy BURZYNSKI STANISLAV R (US) 2008-01-02 — — CN disclosed
CN-1596109-A Preparation containing amino acids and riboflavin for reducing toxic and side effects of cytotoxic chemotherapy BURZYNSKI STANISLAV R (US) 2005-03-16 — — CN disclosed
CN-1160127-C Powdery pernasal compositions ������������ʽ���� 2004-08-04 — — CN disclosed
CN-1287495-A Powdery pernasal compositions TEIJIN LTD (JP) 2001-03-14 — — CN disclosed