Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.37 |
| ▸ | CHIT1 | Q13231 | 2/20 | 0.36 |
| ▸ | CHIA | Q9BZP6 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896811 | 0.76 | KDM4E (0.41) | — | |
| SCHEMBL644676 | 0.75 | HRH4 (0.36) | JAK2JAK1 | |
| SCHEMBL20473440 | 0.74 | L3MBTL3 (0.45) | SLC18A3 | |
| SCHEMBL18866160 | 0.74 | RAB9A (0.38) | CYP3A4 | |
| SCHEMBL2765846 | 0.74 | KMT2A (0.38) | JAK2JAK1 | |
| SCHEMBL2382277 | 0.74 | KMT2A (0.38) | JAK2JAK1 | |
| SCHEMBL389567 | 0.74 | KMT2A (0.38) | JAK2JAK1 | |
| SCHEMBL30463126 | 0.74 | KMT2A (0.38) | JAK2JAK1 | |
| SCHEMBL25040535 | 0.73 | KCNH2 (0.41) | PARP1KCNH2 | |
| SCHEMBL15587343 | 0.73 | KCNH2 (0.41) | PARP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892892-A1 | IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR!THE TREATMENT OF CANCER | Janssen Pharmaceutica N.V. (BE) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014039769-A1 | IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR|THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-13 | — | — | WO | disclosed |