Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexbrompheniramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 5/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 5/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 5/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 4/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 1.00 |
| ▸ | HTR2A | P28223 | 4/20 | 1.00 |
| ▸ | SCN1A | P35498 | 3/20 | 1.00 |
| ▸ | SCN2A | Q99250 | 3/20 | 1.00 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | THPO | P40225 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Brompheniramine SCHEMBL1604455 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL15516706 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL30182709 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL4814 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL4314531 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Dexbrompheniramine SCHEMBL29345 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL6859988 | 0.99 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Dexbrompheniramine SCHEMBL28086608 | 0.99 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Dexbrompheniramine SCHEMBL3744666 | 0.94 | CHRM2 (0.88) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL1901052 | 0.94 | CHRM2 (0.88) | CHRM2SLC6A2SLC6A4HRH1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892518-A2 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | Pharnext (FR) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014037416-A2 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | PHARNEXT (FR) | 2014-03-13 | — | — | WO | disclosed |