Dexbrompheniramine

Dexbrompheniramine

SCHEMBL29345

CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH1

The experimentally established mechanism targets of Dexbrompheniramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 known ✓ P35367 5/20 1.00
CHRM2 P08172 5/20 1.00
SLC6A2 P23975 5/20 1.00
SLC6A4 P31645 5/20 1.00
CHRM1 P11229 4/20 1.00
SLC6A3 Q01959 4/20 1.00
KCNH2 Q12809 4/20 1.00
HRH3 Q9Y5N1 4/20 1.00
HTR2A P28223 4/20 1.00
SCN1A P35498 3/20 1.00
SCN2A Q99250 3/20 1.00
SCN3A Q9NY46 3/20 1.00
ADRA2B P18089 3/20 1.00
LMNA P02545 3/20 1.00
DRD1 P21728 2/20 1.00
CYP2D6 P10635 2/20 1.00
NFKB1 P19838 2/20 1.00
THPO P40225 2/20 1.00
HTR2C P28335 2/20 1.00
HIF1A Q16665 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dexbrompheniramine SCHEMBL15516617 1.00 CHRM2 (1.00) CHRM2SLC6A2SLC6A4HRH1CHRM1
Brompheniramine SCHEMBL1604455 1.00 CHRM2 (1.00) CHRM2SLC6A2SLC6A4HRH1CHRM1
Brompheniramine SCHEMBL15516706 1.00 CHRM2 (1.00) CHRM2SLC6A2SLC6A4HRH1CHRM1
Brompheniramine SCHEMBL30182709 1.00 CHRM2 (1.00) CHRM2SLC6A2SLC6A4HRH1CHRM1
Brompheniramine SCHEMBL4814 1.00 CHRM2 (1.00) CHRM2SLC6A2SLC6A4HRH1CHRM1
Brompheniramine SCHEMBL4314531 1.00 CHRM2 (1.00) CHRM2SLC6A2SLC6A4HRH1CHRM1
Brompheniramine SCHEMBL6859988 0.99 CHRM2 (0.97) CHRM2SLC6A2SLC6A4HRH1CHRM1
Dexbrompheniramine SCHEMBL28086608 0.99 CHRM2 (0.97) CHRM2SLC6A2SLC6A4HRH1CHRM1
Dexbrompheniramine SCHEMBL3744666 0.94 CHRM2 (0.88) CHRM2SLC6A2SLC6A4HRH1CHRM1
Brompheniramine SCHEMBL1901052 0.94 CHRM2 (0.88) CHRM2SLC6A2SLC6A4HRH1CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4148 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 WO claimed
EP-4731194-A1 MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT CSP Technologies, Inc. (US) 2026-04-29 EP claimed
EP-4704971-A1 GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY Cognito Therapeutics, Inc. (US) 2026-03-11 EP claimed
EP-4691492-A2 LIQUID COMPOSITIONS Kenvue Brands LLC (US) 2026-02-11 EP claimed
WO-2025264260-A1 MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT CSP TECHNOLOGIES, INC. (US) 2025-12-26 WO claimed
US-20250332088-A1 SUSTAINED RELEASE COMPOSITIONS RUBICON RES PRIVATE LIMITED (IN) 2025-10-30 US claimed
EP-4630401-A2 CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF Rutgers, the State University of New Jersey (US) 2025-10-15 EP claimed
EP-4247331-B1 ORODISPERSIBLE POWDER COMPOSITION COMPRISING AN ANTIHISTAMINE COMPOUND BIOPHARMA SYNERGIES S L (ES) 2025-10-08 EP claimed
US-20250255781-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-14 US claimed
US-20250177398-A1 CARBONIC ANHYDRASE ENZYMES FOR REGULATING MAST CELL HEMATOPOIESIS AND TYPE 2 INFLAMMATION RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2025-06-05 US claimed
EP-0097523-B1 EXTENDED ACTION CONTROLLED RELEASE COMPOSITIONS Euroceltique S.A. (LU) 1988-01-13 EP claimed
US-4657757-A Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate SCHERING CORPORATION (US) 1987-04-14 US claimed
US-4619934-A AND ANTIHISTAMINE, DECONGESTANT, ANTITUSSIVE OR EXPECTORANT ANALGESIC ASSOCIATES (US) 1986-10-28 US claimed
US-4601894-A ANALGLE0ICS SCHERING CORPORATION (US) 1986-07-22 US claimed
EP-0180597-A1 COUGH/COLD MIXTURES COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS. SUNSHINE ABRAHAM (US) 1986-05-14 EP claimed
WO-1985004589-A1 COUGH/COLD MIXTURES COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS SUNSHINE ABRAHAM 1985-10-24 WO claimed
US-4443428-A PARAFFIN WAXES, ALCOHOLS, FREE BASE AND SALT MIXTURES EUROCELTIQUE, S.A. (LU) 1984-04-17 US claimed
EP-0097523-A2 Extended action controlled release compositions Euroceltique S.A. (LU) 1984-01-04 EP claimed
US-4104382-A (((THIAZOLYL-, ISOTHIAZOLYL- OR PYRIDYLALKYL)THIO)ALKYL)GUANIDINE SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-08-01 US claimed
US-4000302-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-12-28 US claimed