Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Brompheniramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 5/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 5/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 5/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 4/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 1.00 |
| ▸ | HTR2A | P28223 | 4/20 | 1.00 |
| ▸ | SCN1A | P35498 | 3/20 | 1.00 |
| ▸ | SCN2A | Q99250 | 3/20 | 1.00 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | THPO | P40225 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexbrompheniramine SCHEMBL15516617 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL1604455 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL15516706 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL30182709 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL4814 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Dexbrompheniramine SCHEMBL29345 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL6859988 | 0.99 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Dexbrompheniramine SCHEMBL28086608 | 0.99 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Dexbrompheniramine SCHEMBL3744666 | 0.94 | CHRM2 (0.88) | CHRM2SLC6A2SLC6A4HRH1CHRM1 | |
| Brompheniramine SCHEMBL1901052 | 0.94 | CHRM2 (0.88) | CHRM2SLC6A2SLC6A4HRH1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10877035-B2 | Advanced drug development and manufacturing | ICAGEN, LLC (US) | 2020-12-29 | — | — | US | disclosed |
| EP-3137065-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | Pharnext (FR) | 2017-03-08 | — | — | EP | disclosed |
| WO-2015165948-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | PHARNEXT (FR) | 2015-11-05 | — | — | WO | disclosed |
| US-20150309021-A1 | Advanced Drug Development and Manufacturing | LOS ALAMOS NATIONAL SECURITY, LLC | 2015-10-29 | — | — | US | disclosed |
| EP-2511844-B1 | X-ray microscope | XRPRO SCIENCES INC (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-2511844-A2 | Advanced drug development and manufacturing | Los Alamos National Security, LLC (US) | 2012-10-17 | — | — | EP | disclosed |
| EP-2084519-B1 | X-RAY FLUORESCENCE ANALYSIS METHOD | LOS ALAMOS NAT SECURITY LLC (US) | 2012-08-01 | — | — | EP | disclosed |
| EP-2084519-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | Los Alamos National Security, LLC (US) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008127291-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | LOS ALAMOS NATIONAL SECURITY, LLC (US) | 2008-10-23 | — | — | WO | disclosed |
| US-20080220441-A1 | Advanced drug development and manufacturing | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-11 | — | — | US | disclosed |
| EP-1115372-B1 | FAST DISSOLVING ORALLY CONSUMABLE FILMS | WARNER LAMBERT CO (US) | 2006-05-17 | — | — | EP | disclosed |
| US-6033685-A | Tablet for the controlled release of active agents | ABBOTT LABORATORIES (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0951279-A1 | TABLET FOR THE CONTROLLED RELEASE OF ACTIVE AGENTS | Abbott Laboratories (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998030208-A1 | TABLET FOR THE CONTROLLED RELEASE OF ACTIVE AGENTS | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |
| EP-0294993-B1 | A GENERIC ZERO ORDER CONTROLLED DRUG DELIVERY SYSTEM | PFIZER INC. (US) | 1991-07-03 | — | — | EP | disclosed |
| US-4792448-A | Generic zero order controlled drug delivery system | PFIZER INC. (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0294993-A1 | A generic zero order controlled drug delivery system | PFIZER INC. (US) | 1988-12-14 | — | — | EP | disclosed |