Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rilmenidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH known ✓ | Q9Y2I1 | 6/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 12/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 12/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 11/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rilmenidine SCHEMBL114420 | 1.00 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CNISCHADRA1A | |
| SCHEMBL6368709 | 0.91 | ADRA2A (0.83) | ADRA2AADRA2BADRA2CNISCHADRA1A | |
| Rilmenidine SCHEMBL1231349 | 0.90 | ADRA2A (0.81) | ADRA2AADRA2BADRA2CNISCHADRA1A | |
| Rilmenidine SCHEMBL6373730 | 0.86 | ADRA2A (0.73) | ADRA2AADRA2BADRA2CNISCHADRA1A | |
| Rilmenidine SCHEMBL30892124 | 0.86 | CYP3A4 (1.00) | ADRA2AADRA2BADRA2CNISCHADRA1A | |
| SCHEMBL11639239 | 0.81 | ADRA2A (0.68) | ADRA2AADRA2BADRA2CNISCHADRA1A | |
| SCHEMBL11668019 | 0.78 | ADRA2A (0.64) | ADRA2AADRA2BADRA2CNISCHADRA1A | |
| SCHEMBL11140750 | 0.77 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CNISCHADRA1A | |
| SCHEMBL13616145 | 0.77 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CNISCHADRA1A | |
| SCHEMBL11638113 | 0.77 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CNISCHADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137065-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | Pharnext (FR) | 2017-03-08 | — | — | EP | disclosed |
| WO-2015165948-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | PHARNEXT (FR) | 2015-11-05 | — | — | WO | disclosed |
| EP-2892518-A2 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | Pharnext (FR) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014037416-A2 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | PHARNEXT (FR) | 2014-03-13 | — | — | WO | disclosed |