Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rilmenidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH known ✓ | Q9Y2I1 | 3/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 10/20 | 0.73 |
| ▸ | ADRA2B | P18089 | 10/20 | 0.73 |
| ▸ | ADRA2C | P18825 | 9/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.73 |
| ▸ | GMNN | O75496 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | HTR1A | P08908 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rilmenidine SCHEMBL114420 | 0.86 | ADRA2A (1.00) | CYP3A4POLBKDM4EMAPTNFKB1 | |
| SCHEMBL6368709 | 0.78 | ADRA2A (0.83) | CYP3A4POLBKDM4EMAPTNFKB1 | |
| Rilmenidine SCHEMBL6373730 | 0.73 | ADRA2A (0.73) | CYP3A4POLBKDM4EMAPTNFKB1 | |
| Fumaric Acid SCHEMBL11639828 | 0.71 | NFKB1 (0.55) | CYP3A4POLBKDM4EMAPTNFKB1 | |
| SCHEMBL11668019 | 0.67 | ADRA2A (0.64) | CYP3A4POLBKDM4EMAPTNFKB1 | |
| SCHEMBL11140750 | 0.66 | ADRA2A (0.62) | CYP3A4POLBKDM4EMAPTNFKB1 | |
| SCHEMBL6369410 | 0.63 | ADRA2A (0.57) | CYP3A4POLBKDM4EMAPTNFKB1 | |
| SCHEMBL6367795 | 0.63 | ADRA2A (0.57) | CYP3A4POLBKDM4EMAPTNFKB1 | |
| SCHEMBL6367792 | 0.63 | ADRA2A (0.57) | CYP3A4POLBKDM4EMAPTNFKB1 | |
| SCHEMBL12870235 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240299391-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF DIAMOND BLACKFAN ANEMIA | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2024-09-12 | — | — | US | disclosed |
| US-11980620-B2 | Compounds and methods for treatment of Diamond Blackfan anemia | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2024-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240299391-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF DIAMOND BLACKFAN ANEMIA | RPS3A, BECN1, RPS2 | NISCH 3410/4885CYP3A4 4519/4885POLB 1044/4885 |
| US-11980620-B2 | Compounds and methods for treatment of Diamond Blackfan anemia | RPS3A, BECN1, RPS2 | NISCH 3410/4885CYP3A4 4519/4885POLB 1044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.