Stagonolide F

Stagonolide F

SCHEMBL15516703

C[C@@H]1C/C=C/[C@H](O)CCCC(=O)O1

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.44
CA9 Q16790 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.35
CCNA2 P20248 4/20 0.35
CDK2 P24941 4/20 0.35
CCNA1 P78396 4/20 0.35
MKNK2 Q9HBH9 4/20 0.35
MKNK1 Q9BUB5 3/20 0.35
PLK4 O00444 2/20 0.35
CDK1 P06493 2/20 0.35
AXL P30530 2/20 0.35
FLT3 P36888 2/20 0.35
CDK5 Q00535 2/20 0.35
PRKCE Q02156 2/20 0.35
KIT P10721 2/20 0.35
PDGFRA P16234 2/20 0.35
KDR P35968 2/20 0.35
LCK P06239 1/20 0.35
RET P07949 1/20 0.35
MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Stagonolide F SCHEMBL16940586 1.00 CA1 (0.44) CA1CA9SMN1; SMN2CCNA2CDK2
SCHEMBL16944339 0.83 CA1 (0.47) CA1CA9SMN1; SMN2CCNA2CDK2
SCHEMBL14959174 0.79 CA1 (0.43) CA1CA9SMN1; SMN2CCNA2CDK2
SCHEMBL11956113 0.72
SCHEMBL538695 0.72
SCHEMBL18268911 0.72
Stagonolide C SCHEMBL16940571 0.71 CA1 (0.53) CA1CA9SMN1; SMN2NPC1RAB9A
SCHEMBL22734491 0.71 MKNK2 (0.45) CA1CA9SMN1; SMN2MKNK2MKNK1
SCHEMBL18085185 0.71 SMN1; SMN2 (0.39) CA1CA9SMN1; SMN2CCNA2CDK2
SCHEMBL7468957 0.71 MKNK2 (0.45) CA1CA9SMN1; SMN2MKNK2MKNK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160272609-A1 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-09-22 US claimed
US-20150210665-A1 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2015-07-30 US claimed
CN-110628649-B Paecilomyces lilacinus strain, application thereof and method for extracting toxin from paecilomyces lilacinus strain 华南农业大学 2022-02-11 CN disclosed
CN-110628649-A Paecilomyces lilacinus strain, application thereof and method for extracting toxin from paecilomyces lilacinus strain 华南农业大学 2019-12-31 CN disclosed
US-9809566-B2 Organocatalytic process for asymmetric synthesis of decanolides COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2017-11-07 US disclosed
US-9809566-B2 Organocatalytic process for asymmetric synthesis of decanolides COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2017-11-07 US disclosed
US-9809566-B2 Organocatalytic process for asymmetric synthesis of decanolides COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2017-11-07 US disclosed
US-9765048-B2 Organocatalytic process for asymmetric synthesis of decanolides COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2017-09-19 US disclosed
US-9765048-B2 Organocatalytic process for asymmetric synthesis of decanolides COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2017-09-19 US disclosed
US-9765048-B2 Organocatalytic process for asymmetric synthesis of decanolides COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2017-09-19 US disclosed
US-20160272608-A1 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-09-22 US disclosed
US-20160272608-A1 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-09-22 US disclosed
US-20160272609-A1 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-09-22 US disclosed
US-9353077-B2 Organocatalytic process for asymmetric synthesis of decanolides COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-05-31 US disclosed
US-9353077-B2 Organocatalytic process for asymmetric synthesis of decanolides COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-05-31 US disclosed
US-9353077-B2 Organocatalytic process for asymmetric synthesis of decanolides COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-05-31 US disclosed
US-20150210665-A1 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2015-07-30 US disclosed
US-20150210665-A1 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2015-07-30 US disclosed
US-20150210665-A1 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2015-07-30 US disclosed
WO-2014037964-A2 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2014-03-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160272609-A1 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES CDC14A, CDC14B, DDOST CA1 2358/4885CA9 1476/4885SMN1; SMN2 4744/4885
US-20150210665-A1 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES CDC14A, CDC14B, DDOST CA1 2358/4885CA9 1476/4885SMN1; SMN2 4744/4885
US-20160272608-A1 ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES CDC14A, CDC14B, DDOST CA1 2358/4885CA9 1476/4885SMN1; SMN2 4744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.