Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.52 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924155 | 0.92 | MAPT (0.48) | CNR2CNR1MAPTFLT3SMN1; SMN2 | |
| SCHEMBL1415081 | 0.81 | GRM4 (0.46) | MAPTFLT3KMT2AGRM4ALDH1A1 | |
| SCHEMBL15521007 | 0.81 | GRM4 (0.49) | MAPTKMT2AGRM4ALDH1A1KDM4E | |
| SCHEMBL3362693 | 0.78 | MEN1 (0.56) | CNR2CNR1KMT2AGRM4ALDH1A1 | |
| SCHEMBL2466571 | 0.75 | MAPK1 (0.52) | MAPTSMN1; SMN2KMT2AALDH1A1CYP2C9 | |
| SCHEMBL2928975 | 0.74 | GRM4 (0.49) | MAPTKMT2AGRM4ALDH1A1KDM4E | |
| SCHEMBL519451 | 0.74 | LTA4H (0.71) | MAPTSMN1; SMN2ALDH1A1KDM4ENPC1 | |
| SCHEMBL2717838 | 0.73 | CYP1A2 (0.52) | MAPTSMN1; SMN2KMT2AALDH1A1CYP2D6 | |
| SCHEMBL3944864 | 0.73 | CTSB (0.60) | MAPTSMN1; SMN2KMT2AALDH1A1CYP2D6 | |
| SCHEMBL15741625 | 0.73 | POLB (0.55) | MAPTSMN1; SMN2KMT2AALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249125-B2 | Pyrazole derivatives as p38 MAP inhibitors | RESPIVERT LIMITED (GB) | 2016-02-02 | — | — | US | disclosed |
| US-20150203475-A1 | PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS | TOPIVERT PHARMA LIMITED (GB) | 2015-07-23 | — | — | US | disclosed |
| EP-2890693-A1 | PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS | Respivert Limited (GB) | 2015-07-08 | — | — | EP | disclosed |
| WO-2014033448-A1 | PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS | RESPIVERT LIMTED (GB) | 2014-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203475-A1 | PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS | SYK, FYN, MAPK1 | CNR2 2169/4885CNR1 2351/4885MAPT 1617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.