Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | GRK2 | P25098 | 5/20 | 0.45 |
| ▸ | GRK5 | P34947 | 2/20 | 0.45 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | GRK6 | P43250 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.42 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.42 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3336157 | 0.81 | ROCK2 (0.49) | ACVR1PIM1PIM3PIM2GRK2 | |
| SCHEMBL3334866 | 0.79 | MAP4K4 (0.57) | MAP4K4RAF1BRAFCYP1A2CYP2C9 | |
| SCHEMBL13874691 | 0.77 | MAP4K4 (0.60) | ACVR1PIM1PIM3PIM2MAP4K4 | |
| SCHEMBL3334925 | 0.77 | PIK3CD (0.58) | MAP4K4RAF1BRAF | |
| SCHEMBL14595786 | 0.73 | IRAK4 (0.48) | MAP4K4CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL4357306 | 0.73 | CYP1A2 (0.52) | ACVR1PIM1PIM3PIM2MAP4K4 | |
| SCHEMBL2621728 | 0.72 | RAB9A (0.47) | MAP4K4CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL3865271 | 0.72 | HTT (0.56) | CYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL3338478 | 0.72 | RAB9A (0.56) | MAP4K4RAF1BRAFCYP1A2RAB9A | |
| SCHEMBL3848789 | 0.72 | ACVR1 (0.47) | ACVR1PIM1PIM3PIM2GRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673929-B2 | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2014-03-18 | — | — | US | claimed |