⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2342739 | 0.78 | — | — | |
| SCHEMBL4319053 | 0.76 | — | — | |
| SCHEMBL4196358 | 0.76 | — | — | |
| SCHEMBL918055 | 0.76 | — | — | |
| SCHEMBL9816263 | 0.74 | KMT2A (0.52) | — | |
| SCHEMBL11230938 | 0.74 | KMT2A (0.52) | — | |
| SCHEMBL2948875 | 0.74 | KMT2A (0.52) | — | |
| SCHEMBL7530097 | 0.74 | KMT2A (0.52) | — | |
| SCHEMBL6627461 | 0.74 | — | — | |
| SCHEMBL3540533 | 0.72 | TLR4 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4211119-B1 | 2-AMINOQUINAZOLINES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2026-05-13 | — | — | EP | disclosed |
| US-12570640-B2 | 2-aminoquinazolines as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof | MERCK SHARP & DOHME LLC (US) | 2026-03-10 | — | — | US | disclosed |
| CN-121586717-A | Heteroaryl compounds, process for their preparation and their use in medicine | 江苏恒瑞医药股份有限公司 | 2026-02-27 | — | — | CN | disclosed |
| US-12527790-B2 | Checkpoint kinase 1 (CHK1) inhibitors and uses thereof | BOUNDLESS BIO, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| EP-4371987-B9 | SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS | GILEAD SCIENCES INC (US) | 2025-11-26 | — | — | EP | disclosed |
| WO-2025235872-A1 | HETEROCYCLICS AS EGFR INHIBITORS | SCHRÖDINGER, INC. (US) | 2025-11-13 | — | — | WO | disclosed |
| WO-2025184391-A9 | COVALENT INHIBITORS AND USES THEREOF | ARRAKIS THERAPEUTICS, INC. (US) | 2025-10-30 | — | — | WO | disclosed |
| EP-4371987-B1 | SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS | GILEAD SCIENCES INC (US) | 2025-09-17 | — | — | EP | disclosed |
| EP-4587438-A1 | BICYCLIC COMPOUNDS AS CDK INHIBITORS | BeiGene Switzerland GmbH (CH) | 2025-07-23 | — | — | EP | disclosed |
| WO-2025137507-A1 | SOS1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. (US) | 2025-06-26 | — | — | WO | disclosed |
| WO-2011043817-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | CORNELL UNIVERSITY (US) | 2011-04-14 | — | — | WO | disclosed |
| WO-2010006086-A2 | KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE, INC. (US) | 2010-01-14 | — | — | WO | disclosed |
| EP-1192145-A4 | PROCESS FOR PREPARING CHIRAL CYCLOPROPANE CARBOXYLIC ACIDS AND ACYL GUANIDINES | BRISTOL MYERS SQUIBB CO (US) | 2003-01-29 | — | — | EP | disclosed |
| EP-1192145-A1 | PROCESS FOR PREPARING CHIRAL CYCLOPROPANE CARBOXYLIC ACIDS AND ACYL GUANIDINES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076991-A1 | PROCESS FOR PREPARING CHIRAL CYCLOPROPANE CARBOXYLIC ACIDS AND ACYL GUANIDINES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |
| US-6160134-A | Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines | BRISTOL-MYERS SQUIBB CO. (US) | 2000-12-12 | — | — | US | disclosed |
| US-4529813-A | Preparation of 2-halogeno-3-alkylvinylcyclobutan-1-one | BAYER AKTIENGESELLSCHAFT (DE) | 1985-07-16 | — | — | US | disclosed |
| EP-0050777-A2 | Preparation of cyclopropane-carboxylic-acid-substituted chloro-fluoro-alkyl esters, their derivatives and intermediates | BAYER AG (DE) | 1982-05-05 | — | — | EP | disclosed |
| US-4291176-A | Production of insecticidally active vinyl-cyclopropane carboxylic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1981-09-22 | — | — | US | disclosed |
| EP-0019132-A1 | Process for the preparation of alpha-halogen cyclobutanones | BAYER AG (DE) | 1980-11-26 | — | — | EP | disclosed |