Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 6/20 | 0.43 |
| ▸ | CA2 | P00918 | 6/20 | 0.43 |
| ▸ | CA9 | Q16790 | 6/20 | 0.43 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA3 | P07451 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA6 | P23280 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8838290 | 1.00 | MEN1 (0.56) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL7858967 | 1.00 | MEN1 (0.56) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL9949427 | 1.00 | MEN1 (0.56) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL8501137 | 1.00 | MEN1 (0.56) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL2528256 | 1.00 | MEN1 (0.56) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL23149781 | 1.00 | MEN1 (0.56) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL2532247 | 0.97 | MEN1 (0.52) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL7702021 | 0.95 | MEN1 (0.56) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL4293421 | 0.95 | MEN1 (0.56) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL14360432 | 0.95 | MEN1 (0.56) | MEN1THRBHTTKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240217938-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | EMERGENT BIODEFENSE OPERATIONS LANSING LLC | 2024-07-04 | — | — | US | disclosed |
| US-11912667-B2 | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof | EMERGENT BIODEFENSE OPERATIONS LANSING LLC (US) | 2024-02-27 | — | — | US | disclosed |
| US-20220144782-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | EMERGENT BIODEFENSE OPERATIONS LANSING LLC | 2022-05-12 | — | — | US | disclosed |
| US-20220033432-A1 | ANTI-HEPATITIS B VIRUS AGENT | DAIKIN INDUSTRIES, LTD. (JP) | 2022-02-03 | — | — | US | disclosed |
| EP-3939655-A1 | ANTI-HEPATITIS B VIRUS AGENT | DAIKIN INDUSTRIES, LTD. (JP) | 2022-01-19 | — | — | EP | disclosed |
| US-20220008450-A1 | ANTI-HEPATITIS B VIRUS AGENT | DAIKIN INDUSTRIES, LTD. (JP) | 2022-01-13 | — | — | US | disclosed |
| EP-3862004-A1 | ANTI-HEPATITIS B VIRUS AGENT | DAIKIN INDUSTRIES, LTD. (JP) | 2021-08-11 | — | — | EP | disclosed |
| US-11066373-B2 | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof | CHIMERIX, INC. (US) | 2021-07-20 | — | — | US | disclosed |
| CN-112805011-A | Anti-hepatitis B virus agents | 大金工业株式会社 | 2021-05-14 | — | — | CN | disclosed |
| WO-2020213501-A1 | NUCLEIC ACID ANALOG AND ANTI-HEPATITIS B VIRUS AGENT | ダイキン工業株式会社 | 2020-10-22 | — | — | WO | disclosed |
| US-20150210724-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | EMERGENT BIODEFENSE OPERATIONS LANSING LLC | 2015-07-30 | — | — | US | disclosed |
| WO-2015073148-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS | CHIMERIX INC. (US) | 2015-05-21 | — | — | WO | disclosed |
| US-8962829-B1 | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof | CHIMERIX, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| CN-104321432-A | Artificial nucleic acid molecules comprising a 5' TOP UTR | CUREVAC GMBH | 2015-01-28 | — | — | CN | disclosed |
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-8569321-B2 | Phosphonate ester derivatives and methods of synthesis thereof | CHIMERIX, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| EP-2611818-A2 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | Chimerix, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| WO-2012031045-A2 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | CHIMERIX, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| WO-1998038202-A1 | ANTIVIRAL PHOSPHONATE PRODRUGS OF NUCLEOSIDES AND NUCLEOSIDE ANALOGUES | DANA-FARBER CANCER INSTITUTE (US) | 1998-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912667-B2 | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof | PHOSPHO1, PPIP5K2, FASN | MEN1 1228/4885THRB 4475/4885HTT 3039/4885 |
| US-20240217938-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | PHOSPHO1, PPIP5K2, FASN | MEN1 1228/4885THRB 4475/4885HTT 3039/4885 |
| US-20220033432-A1 | ANTI-HEPATITIS B VIRUS AGENT | SLC10A1, HAVCR2, FABP1 | MEN1 3422/4885THRB 1927/4885HTT 3489/4885 |
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | MEN1 1891/4885THRB 3673/4885HTT 4129/4885 |
| US-20140046085-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | MEN1 1891/4885THRB 3673/4885HTT 4129/4885 |
| US-20220144782-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | PHOSPHO1, PPIP5K2, FASN | MEN1 1228/4885THRB 4475/4885HTT 3039/4885 |
| US-20150210724-A1 | MORPHIC FORMS OF HEXADECYLOXYPROPYL-PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS THEREOF | PHOSPHO1, PPIP5K2, FASN | MEN1 1228/4885THRB 4475/4885HTT 3039/4885 |
| US-20220008450-A1 | ANTI-HEPATITIS B VIRUS AGENT | HAVCR2, ADAR, ADA | MEN1 4617/4885THRB 1462/4885HTT 3701/4885 |
| US-11066373-B2 | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof | PHOSPHO1, PPIP5K2, FASN | MEN1 1228/4885THRB 4475/4885HTT 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.